原发性肝癌综合治疗的进展和热点

被引：60

作者：

袁声贤

周伟平

机构：

[1] 海军军医大学附属东方肝胆外科医院肝外三科,上海

来源：

中华消化外科杂志 | 2021年 / 20卷 / 02期

关键词：

肝肿瘤; 原发性; 转化治疗; 新辅助治疗; 辅助治疗;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

原发性肝癌(本文特指肝细胞癌, 以下简称肝癌)的治疗原则是以手术为主的综合治疗。围绕提高根治性手术切除率和降低术后复发率等难题, 肝癌的转化治疗、新辅助治疗和术后辅助治疗应运而生, 极大地丰富了综合治疗的内涵, 也成为研究热点。肝癌侵袭转移性强且常合并肝硬化等, 综合治疗必不可少, 但因手术适应证仍存在争议、个体间异质性大等原因, 三种治疗方式尤其是转化治疗和新辅助治疗在概念和治疗方式上并非泾渭分明。治疗目标不同导致治疗方式选择、疗程长短和评估标准等也不同。结合临床实践, 笔者分类论述肝癌的转化治疗、新辅助治疗和术后辅助治疗等最新进展和热点问题, 期待开展更多研究获得临床循证医学证据规范综合治疗, 从而成为提高肝癌诊断与治疗效果的突破口。

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