代谢组学研究进展

被引：120

作者：

许国旺

路鑫

杨胜利

机构：

[1] 中国科学院大连化学物理研究所代谢组学研究中心

来源：

中国医学科学院学报 | 2007年 / 06期

关键词：

代谢组学; 质谱; 系统生物学;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）];

学科分类号：

0836 ; 090102 ;

摘要：

代谢组学是功能基因组学和系统生物学研究不可或缺的重要组成部分,是通过考察生物体系受刺激或扰动前后(如将某个特定的基因变异或环境变化后)代谢产物的动态变化,研究生物体系的代谢网络的一种技术。近年来,在药物研发、疾病研究、植物和微生物等领域发展迅速,但在分析技术、方法学和应用等方面急需突破。

引用

页码：701 / 711

页数：11

共 37 条

[11]

Systems biology, metabolic modelling and metabolomics in drug discovery and development[J] . Douglas B. Kell.Drug Discovery Today . 2006 (23)

[12] Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry [J].

Bajad, Sunil U. ;

Lu, Wenyun ;

Kimball, Elizabeth H. ;

Yuan, Jie ;

Peterson, Celeste ;

Rabinowitz, Joshua D. .

JOURNAL OF CHROMATOGRAPHY A, 2006, 1125 (01) :76-88

[13] Capillary electrophoresis in metabolomics [J].

Ramautar, Rawi ;

Demirci, Ayla ;

de Jong, Gerhardus J. .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2006, 25 (05) :455-466

[14]

Principal component analysis of urine metabolites detected by NMR and DESI–MS in patients with inborn errors of metabolism[J] . Zhengzheng Pan,Haiwei Gu,Nari Talaty,Huanwen Chen,Narasimhamurthy Shanaiah,Bryan E. Hainline,R. Graham Cooks,Daniel Raftery.Analytical and Bioanalytical Chemistry . 2007 (2)

[15]

Toxicology[C]. 2002年中日毒理学和药理学联合研讨会,2002

[16]

A functional analysis of mouse models of cardiac disease through metabolic profiling. Jones G,Sang E,Goddard C, et a. Journal of Biological Chemistry . 2005

[17] Biomarkers for amyotrophic lateral sclerosis [J].

Bowser, Robert ;

Cudkowicz, Merit ;

Kaddurah-Daouk, Rima .

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2006, 6 (03) :387-398

[18] Plasma phospholipid metabolic profiling and biomarkers of mouse IgA nephropathy [J].

Jia, Lewen ;

Wang, Chang ;

Kong, Hongwei ;

Cai, Zongwei ;

Xu, Guowang .

METABOLOMICS, 2006, 2 (02) :95-104

[19]

The Consortium for Metabonomic Toxicology （COMET）: aims, activities and achievements[J] . John C Lindon,Hector C Keun,Timothy MD Ebbels,Jake MT Pearce,Elaine Holmes,Jeremy K Nicholson.Pharmacogenomics . 2005 (7)

[20]

Gas chromatographic–mass spectrometric urinary metabolome analysis to study mutations of inborn errors of metabolism[J] . TomikoKuhara.Mass Spectrom. Rev. . 2005 (6)

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