抗帕金森病药物及其作用靶点研究进展

被引:57
作者
张雪 [1 ]
张雯 [1 ]
杜立达 [2 ]
高丽 [3 ]
杜冠华 [1 ]
机构
[1] “药物靶点研究与新药筛选”北京市重点实验室,中国医学科学院北京协和医学院药物研究所
[2] 香港中文大学生物医学学院
[3] 山西大学中医药现代研究中心
关键词
帕金森病; 抗帕金森病药物; 药物靶点;
D O I
10.13220/j.cnki.jipr.2016.01.013
中图分类号
R971.5 [];
学科分类号
摘要
帕金森病(PD)是一种以黑质纹状体通路神经退行性病变为主要特征的神经系统变性疾病,其临床特征主要表现为静止性震颤、肌肉强直、运动迟缓和姿势平衡障碍,是严重影响人类健康的第二大神经退行性疾病。目前,临床上对PD均采用对症治疗,尚无有效的治疗手段能够恢复变性神经元。在PD的治疗中以药物治疗为主,这些药物主要基于PD发病机制中关键的作用靶点或信号通路而研发,可缓解PD症状。对于防治PD药物的研发一直是医药领域的重要课题。本文对PD相关治疗药物的现状及抗PD药物靶点研究进展做一简要综述。
引用
收藏
页码:87 / 96
页数:10
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