活性维生素D3类药物的研究进展

被引：7

作者：

文鹏

赵梨

吴坚

陆群

机构：

[1] 西南交通大学生命科学与工程学院

来源：

华西药学杂志 | 2011年 / 26卷 / 01期

基金：

中央高校基本科研业务费专项资金资助;

关键词：

活性维生素D3; 结构修饰; 类似物; 构效关系;

D O I：

10.13375/j.cnki.wcjps.2011.01.032

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

通过对活性维生素D3化学结构进行修饰,获得了大量高效低毒的抗癌活性类似物。综述了活性维生素D3的A环结构修饰方法及其类似物的构效关系。

引用

页码：87 / 90

页数：4

共 18 条

[1]

活性维生素D3类药物研究概况 [J].

俞银芳 ;

刘兆鹏 .

中国药物化学杂志, 2006, (05) :311-315

[2]

Synthesis of 2α-propoxy-1α,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1 [J].

Saito, Nozomi ;

Suhara, Yoshitomo ;

Abe, Daisuke ;

Kusudo, Tatsuya ;

Ohta, Miho ;

Yasuda, Kaori ;

Sakaki, Toshiyuki ;

Honzawa, Shinobu ;

Fujishima, Toshie ;

Kittaka, Atsushi .

BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (13) :4296-4301

[3]

Vitamin D analogs: Therapeutic applications and mechanisms for selectivity [J].

Brown, Alex J. ;

Slatopolsky, Eduardo .

MOLECULAR ASPECTS OF MEDICINE, 2008, 29 (06) :433-452

[4]

Analogs of 1α,25-dihydroxyvitamin D3 with high potency in induction of osteoclastogenesis and prevention of dendritic cell differentiation:: Synthesis and biological evaluation of 2-substituted 19-norvitamin D analogs [J].

Shimazaki, Mika ;

Miyamoto, Yukiko ;

Yamamoto, Keiko ;

Yamada, Sachiko ;

Takami, Masamichi ;

Shinki, Toshimasa ;

Udagawa, Nobuyuki ;

Shimizu, Masato .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (13) :4645-4656

[5]

Synthesis and biological activities of new 1α,25-dihydroxy-19-norvitamin D3 analogs with modifications in both the A-ring and the side chain [J].

Shimizu, Masato ;

Miyamoto, Yukiko ;

Kobayashi, Emi ;

Shimazaki, Mika ;

Yamamoto, Keiko ;

Reischl, Wolfgang ;

Yamada, Sachiko .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (12) :4277-4294

[6]

Novel A-ring analogs of the hormone 1α,25-dihydroxyvitamin D3:: synthesis and preliminary biological evaluation [J].

Posner, GH ;

Lee, SHT ;

Kim, HJ ;

Peleg, S ;

Dolan, P ;

Kensler, TW .

BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (08) :2959-2966

[7]

Design, synthesis and biological evaluation of novel 1α,25-dihydroxyvitamin D3 analogues possessing aromatic ring on 2α-position [J].

Honzawa, S ;

Hirasaka, K ;

Yamamoto, Y ;

Peleg, S ;

Fujishima, T ;

Kurihara, M ;

Saito, N ;

Kishimoto, S ;

Sugiura, T ;

Waku, K ;

Hiroaki, TA ;

Kittaka, A .

TETRAHEDRON, 2005, 61 (47) :11253-11263

[8]

Chemoenzymatic synthesis and biological evaluation of C-3 carbamate analogues of 1α,25-dihydroxyvitamin D3 [J].

Gotor-Fernández, V ;

Fernández, S ;

Ferrero, M ;

Gotor, V ;

Bouillon, R ;

Verstuyf, A .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (20) :5443-5451

[9]

New derivative of 1α;25-dihydroxy-19-norvitamin D 3 with 3′-alkoxypropylidene moiety at C-2: synthesis; biological activity and conformational analysis.[J].Agnieszka Glebocka;Rafal R. Sicinski;Hector F. DeLuca.Journal of Steroid Biochemistry and Molecular Biology.2004,

[10]

2;2-Functionalized analogues of 1α;25-dihydroxyvitamin D 3 ; the potent inducers of cell differentiation.[J].Toshie Fujishima;Atsushi Kittaka;Masaaki Kurihara;Nozomi Saito;Shinobu Honzawa;Seishi Kishimoto;Takayuki Sugiura;Keizo Waku;Hiroaki Takayama.Journal of Steroid Biochemistry and Molecular Biology.2004,

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