Novel A-ring analogs of the hormone 1α,25-dihydroxyvitamin D3:: synthesis and preliminary biological evaluation

被引：13

作者：

Posner, GH

Lee, SHT

Kim, HJ

Peleg, S

Dolan, P

Kensler, TW

机构：

[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Med Specialties, Houston, TX 77030 USA

[3] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Div Environm Hlth Sci, Baltimore, MD 21205 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 08期

关键词：

vitamin D analogs; SAR; growth inhibition;

D O I：

10.1016/j.bmc.2005.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Prepared from a commercial prostaglandin building block, novel vitamin D-3 analogs with a contracted five-membered A-ring were designed and synthesized to mimic the A-ring diol structure of the natural hormone lot,1 alpha,25-dihydroxyvitamin D-3- Prepared from commercial 1,4-cyclohexanedione, a structurally simplified analog was designed and synthesized in which a suitably oriented primary allylic hydroxyl group at the C-2 position might be a surrogate for the biologically important lot-OH in the natural hormone. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2959 / 2966

页数：8

共 34 条

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Enzymatic synthesis of a ring-contracted analogue of 5-enolpyruvyishikimate-3-phosphate [J].