电离辐射诱导造血干细胞损伤的分子机制研究进展

被引：10

作者：

方连英

王彦

徐畅

杜利清

王芹

刘强

机构：

[1] 中国医学科学院北京协和医学院放射医学研究所天津市核医学重点实验室

来源：

基础医学与临床 | 2017年 / 37卷 / 02期

基金：

天津市自然科学基金;

关键词：

电离辐射; 造血干细胞; 凋亡; 分化; 衰老;

D O I：

10.16352/j.issn.1001-6325.2017.02.022

中图分类号：

R594.8 [电磁波损害];

学科分类号：

1002 ; 100201 ;

摘要：

电离辐射(IR)诱导的造血干细胞(HSCs)损伤是IR后引发机体死亡的主要原因,其损伤机制主要涉及P53-Puma通路诱导HSCs凋亡;激活G-CSF/Stat3/BATF依赖性的分化检验点促进HSCs分化;ROS-P38通路诱导HSCs衰老以及损伤HSCs龛。近期研究为预防和治疗电离辐射引起的骨髓抑制提供了理论基础。

引用

页码：256 / 260

页数：5

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