AMP活化蛋白激酶与脂肪细胞因子

被引：5

作者：

宋君

李宏亮

李光伟

机构：

[1] 卫生部中日友好医院内分泌代谢病中心

来源：

国际内分泌代谢杂志 | 2008年 / 02期

关键词：

AMPK; 脂肪细胞因子; 脂联素; 瘦素; 抵抗素;

D O I：

暂无

中图分类号：

R587.1 [糖尿病]; R589 [代谢病];

学科分类号：

100201 [内科学];

摘要：

腺苷酸活化蛋白激酶(AMPK)作为细胞重要的能量感受器,能通过增强分解代谢通路,抑制合成代谢通路,调节代谢和能量平衡。近年来研究显示AMPK同样参与了以瘦素、脂联素及抵抗素等为代表的脂肪细胞因子生理作用的发挥,同时AMPK激活亦可影响脂肪细胞因子的分泌,因此脂肪细胞因子与AMPK相关作用机制的研究将为治疗肥胖、糖尿病和代谢综合征提供新的途径。

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