血清维生素D水平与桥本甲状腺炎的相关性分析

被引:19
作者
李娜
蒋筠
严率
方芳
顾丽萍
彭永德
王育璠
机构
[1] 上海交通大学附属第一人民医院内分泌代谢科
关键词
维生素D; 桥本甲状腺炎; 自身免疫性甲状腺疾病;
D O I
10.13683/j.wph.2015.09.004
中图分类号
R581.4 [甲状腺炎];
学科分类号
100201 [内科学];
摘要
目的观察桥本甲状腺炎患者血清维生素D的含量,探讨维生素D与桥本甲状腺炎的关系。方法选取2013年7月至2014年3月在我院就诊的桥本甲状腺炎患者50例,同时选取正常健康对照者56例。收集性别、年龄、身高、体重、体重指数(BMI)、血压、血糖、血脂、钙、磷、甲状旁腺激素(PTH)、甲状腺激素、甲状腺自身抗体及25羟维生素D3[25(OH)D3]等临床资料。比较两组维生素D含量,并对相关指标进行分析。结果与正常对照组相比,桥本甲状腺炎患者血清25(OH)D3水平降低(P<0.05),维生素D不足发生比例升高(P<0.05);桥本甲状腺炎患者促甲状腺激素水平升高(P<0.01),发生亚临床甲减的比例较高(P<0.01)。二元Logistic回归模型分析表明,维生素D为桥本甲状腺炎的保护因素(OR值0.969,P<0.01,95%CI为0.946~0.991),BMI为桥本甲状腺炎的危险因素(OR值1.200,P<0.05,95%CI为1.016~1.417)。结论维生素D缺乏在桥本甲状腺炎患者中发生率较高,维生素D缺乏可能会增加桥本甲状腺炎的风险。
引用
收藏
页码:591 / 595
页数:5
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