BDNF信号通路在天然抗抑郁药中的研究进展

被引：15

作者：

齐卫卫 ^{[1
,2
]}

钟正灵 ^{[2
]}

郭亚鹏 ^{[1
]}

李须逸 ^{[1
,2
]}

童九翠 ^{[2
]}

机构：

[1] 皖南医学院

[2] 皖南医学院弋矶山医院临床药学部

来源：

中国临床药理学与治疗学 | 2016年 / 21卷 / 09期

基金：

安徽省自然科学基金;

关键词：

抑郁症; 抗抑郁药; 天然药物; 脑源性神经营养因子; 信号通路;

D O I：

暂无

中图分类号：

R971.4 [];

学科分类号：

摘要：

脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)作为神经营养因子之一,在抑郁症的发生发展及抗抑郁药的作用过程中发挥着重要的调控作用。研究表明,一些抗抑郁药物通过BDNF信号通路影响神经可塑性及细胞结构来发挥抗抑郁作用。本文参考国内外相关文献,着重阐述与抑郁症相关的BDNF信号通路以及天然抗抑郁药对BDNF信号通路的研究进展,以期为发掘更多的天然抗抑郁药提供思路。

引用

页码：1068 / 1073

页数：6

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