PI3K/Akt信号通路在骨质疏松病理过程中的作用

被引：49

作者：

陈亚辉 ^{[1
]}

龚忠勤 ^{[2
]}

崔燎 ^{[1
,2
]}

机构：

[1] 广东医学院药理学教研室

[2] 广东医学院广东省天然药物研究与开发重点实验室

来源：

中国骨质疏松杂志 | 2015年 / 21卷 / 03期

关键词：

PI3K; Akt; FoxO; Wnt; 骨质疏松;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

磷脂酰肌醇三激酶/蛋白激酶B(PI3K/Akt)信号通路是调节细胞增殖、分化、存活、迁移和代谢过程的最为重要的一个信号通路。越来越多的证据表明,骨组织中的许多信号分子能够选择性激活PI3K/Akt信号通路的相关基因,通过调控成骨细胞和破骨细胞的活动,破坏骨重建过程中骨形成与骨吸收的动态平衡,在骨质疏松的发生和发展中扮演着非常重要的角色。

引用

页码：356 / 360

页数：5

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