芦丁的结构修饰及生物活性研究进展

被引：35

作者：

李珂

冯亚莉

曹瑞梅

陈虹

翟广玉

机构：

[1] 郑州工业应用技术学院药学与化学工程学院

来源：

中草药 | 2021年 / 52卷 / 20期

关键词：

芦丁; 结构修饰; 衍生物; 配合物; 生物活性;

D O I：

暂无

中图分类号：

R284 [中药化学];

学科分类号：

100804 [中药化学];

摘要：

芦丁是一个典型的类黄酮,主要存在于日常食用的各种中草药、水果和蔬菜中。芦丁是天然的抗氧化剂,具有广泛的药理活性,如抗炎、抗病毒、抗肿瘤、预防和治疗心脑血管疾病等作用。由于生物利用度低、水溶性差,限制了其在临床上的应用。通过对芦丁的羟基、羰基、槲皮素A、B环等优化修饰,获得了溶解性好、生物利用度高、代谢稳定和毒副作用小的醚类、酯类、配合物等芦丁衍生物。综述了近年来对芦丁结构修饰后,获得的性能优良、生物活性显著的芦丁衍生物。

引用

页码：6413 / 6424

页数：12

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