单核苷酸多态性与肺癌放射性食管炎相关性的研究

被引：4

作者：

张莉

王绿化

杨明

姬巍

赵路军

杨伟志

周宗玫

欧广飞

林东昕

机构：

[1] 中国医学科学院中国协和医科大学肿瘤医院肿瘤研究所放疗科

来源：

中华放射肿瘤学杂志 | 2008年 / 03期

关键词：

肺肿瘤/放射疗法; 放射性食管炎; 单核苷酸多态性;

D O I：

暂无

中图分类号：

R686 [筋腱、韧带、滑囊疾病及损伤];

学科分类号：

100220 [骨科学];

摘要：

目的探索肺癌放疗中单核苷酸多态性与放射性食管炎的相关性。方法采用聚合酶链反应-限制性内切酶片段长度多态性（PCR-RFLP）方法分析了 DNA 损伤修复通路、凋亡通路和炎症因子相关的20个基因37个单核苷酸多态性位点的基因型,观察放疗中和放疗结束后3个月内发生的≥2级放射性食管炎与其相关性。170例病理证实的不可手术的肺癌患者（非小细胞肺癌127例,小细胞肺癌43例）接受了45～70 Gy（平均60 Gy）的放疗,其中三维适形放疗132例,常规放疗38例;单纯放疗41例,放化疗129例（序贯放化疗78例,同步放化疗51例）。结果 170例中发生≥2放射性食管炎40例,其中2级36例,3级4例。单因素分析结果显示放疗技术、同步放化疗与放射性食管炎的发生有关（P=0.032、0.049）,多因素分析结果接近统计学水平（P=0.072、0.094）。相关性分析显示 TGF-β1-509T 和 XPD 751Lys/Lys 基因型为放射性食管炎的风险基因型（X2=5.65,P=0.017,X2=3.84 P=0.048）。结论 TGF-β1-509C/T 和 XPD Lys751Gln 多态性与肺癌放射性食管炎的发生有显著相关性。

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