Notch信号通路在骨重建中的作用

被引：8

作者：

何子豪

于志锋

机构：

[1] 上海交通大学医学院附属第九人民医院骨科上海市骨科内植物重点实验室

来源：

医用生物力学 | 2018年 / 33卷 / 01期

关键词：

Notch信号通路; 骨重建; 成骨细胞; 骨细胞; 破骨细胞;

D O I：

10.16156/j.1004-7220.2018.01.015

中图分类号：

R68 [骨科学（运动系疾病、矫形外科学）];

学科分类号：

100220 [骨科学];

摘要：

Notch信号通路在胚胎发育、神经系统、血管系统、内分泌系统及肿瘤等领域具有广泛的影响。近年来的研究表明,Notch对于骨组织代谢尤其是骨重建有着重要的调控作用,而骨重建的调节紊乱和骨质疏松、骨关节炎等疾病的进展密切相关。Notch信号通路可以通过调控骨组织不同细胞的功能从而影响骨重建过程,但其在不同细胞中具体的参与方式仍然未知。综述近年来Notch信号通路在骨重建中的作用研究进展。

引用

页码：89 / 94

页数：6

共 9 条

[1]

The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool [J].

Lawal, Rialnat A. ;

Zhou, Xichao ;

Batey, Kaylind ;

Hoffman, Corey M. ;

Georger, Mary A. ;

Radtke, Freddy ;

Hilton, Matthew J. ;

Xing, Lianping ;

Frisch, Benjamin J. ;

Calvi, Laura M. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2017, 32 (06) :1320-1331

[2]

A top-notch dilemma: The complex role of NOTCH signaling in osteoarthritis [J].

Ratneswaran, Anusha ;

Beier, Frank .

SCIENCE SIGNALING, 2015, 8 (386)

[3]

Estrogen improves the proliferation and differentiation of hBMSCs derived from postmenopausal osteoporosis through notch signaling pathway [J].

Fan, Jin-Zhu ;

Yang, Liu ;

Meng, Guo-Lin ;

Lin, Yan-shui ;

Wei, Bo-Yuan ;

Fan, Jing ;

Hu, Hui-Min ;

Liu, Yan-Wu ;

Chen, Shi ;

Zhang, Jin-Kang ;

He, Qi-Zhen ;

Luo, Zhuo-Jing ;

Liu, Jian .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2014, 392 (1-2) :85-93

[4]

Hairy and Enhancer of Split-related with YRPW Motif (HEY)2 Regulates Bone Remodeling in Mice [J].

Zanotti, Stefano ;

Canalis, Ernesto .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (30) :21547-21557

[5]

Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9 [J].

Chen, Shan ;

Tao, Jianning ;

Bae, Yangjin ;

Jiang, Ming-Ming ;

Bertin, Terry ;

Chen, Yuqing ;

Yang, Tao ;

Lee, Brendan .

JOURNAL OF BONE AND MINERAL RESEARCH, 2013, 28 (03) :649-659

[6]

Stimulation of Osteoblastic Cell Differentiation by Notch.[J].Ken‐ICHITezuka;MasafumiYasuda;NaokoWatanabe;NaokoMorimura;KazukiKuroda;SeijiMiyatani;NobumichiHozumi.J Bone Miner Res.2009, 2

[7]

Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone.[J].Rishard Salie;Michaela Kneissel;Mirko Vukevic;Natasa Zamurovic;Ina Kramer;Glenda Evans;Nicole Gerwin;Matthias Mueller;Bernd Kinzel;Mira Susa.Bone.2009, 3

[8]

Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study.[J]..Osteoporosis International.2009, 1

[9]

Parathyroid hormone stimulates expression of the Notch ligand Jagged1 in osteoblastic cells.[J].Jonathan M. Weber;Shaula R. Forsythe;Christina A. Christianson;Benjamin J. Frisch;Benjamin J. Gigliotti;Craig T. Jordan;Laurie A. Milner;Monica L. Guzman;Laura M. Calvi.Bone.2006, 3

← 1 →