增龄性变化对大鼠骨质量、血清骨代谢指标影响研究

被引：2

作者：

张银萍

郭雄

张增铁

耿冬

机构：

[1] 西安交通大学医学院

来源：

护理研究 | 2008年 / 29期

关键词：

骨质疏松症; 老龄; 大鼠; 骨密度; 骨代谢;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

[目的]探讨增龄性变化对大鼠骨质量、血清骨代谢指标的影响。[方法]14只新生雄性Sprague Dawley(SD)大鼠,同等条件下饲养,饲养至6个月按体重随机分为老龄骨质疏松组(AO组)和青年对照组(YC组),将YC组安乐处死,AO组继续饲养至22个月,两组大鼠均取左侧股骨,测量骨密度、骨组织形态计量学指标,以及骨矿水平及骨代谢指标。[结果]腰椎及股骨密度(BMD)在老龄大鼠均下降,其中股骨密度下降尤其显著(P<0.01)。与YC组比较,AO组大鼠骨钙素水平显著降低(P<0.01),抗酒石酸酸性磷酸酶(TRACP)水平显著升高(P<0.05);骨生物力学测定发现,AO组大鼠的股骨最大受力负荷下降。骨形态计量学测定发现,AO组大鼠骨小梁体积、骨小梁宽度、骨皮质厚度显著下降(P<0.05或P<0.01),骨小梁间隙增大(P<0.01),AO组大鼠骨小梁普遍变薄、变细甚至断裂穿孔。[结论]22月龄雄性大鼠发生了骨质疏松的变化,骨形成降低,骨矿含量下降,骨微观组织结构破坏。

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页码：2639 / 2641

页数：3

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