共刺激分子CD40/CD40L及B7/CD28与动脉粥样硬化

被引：3

作者：

战萍萍

李玉杰

机构：

[1] 中山大学附属第一医院急诊科

来源：

国际内科学杂志 | 2007年 / 08期

基金：

广东省自然科学基金; 广东省科技计划;

关键词：

共刺激分子; CD40; CD40L; B7; CD28; 动脉粥样硬化;

D O I：

暂无

中图分类号：

R543 [血管疾病];

学科分类号：

1002 ; 100201 ;

摘要：

共刺激分子CD40/CD40L及B7/CD28是T细胞活化的两条重要辅助刺激通路,不仅在调节T细胞免疫反应中起关键作用,而且也在B细胞的活化、增殖、分化、抗体的分泌起重要作用。近年来它们在动脉粥样硬化方面的研究成为国内外学者研究的热点。对共刺激分子和动脉粥样硬化关系的深入了解,将有助于阐明动脉粥样硬化发生的炎症和免疫机制,并为临床治疗开辟新途径。本文综述了共刺激分子的免疫学特征及功能以及在动脉粥样硬化中发挥的作用与免疫学治疗的前景。

引用

收藏

页码：467 / 470

页数：4

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