软骨下骨成骨细胞在骨性关节炎中的作用与机制

被引：12

作者：

张立智

张世民

机构：

[1] 同济大学附属杨浦医院骨科

来源：

中华骨质疏松和骨矿盐疾病杂志 | 2014年 / 7卷 / 02期

基金：

上海市自然科学基金;

关键词：

骨性关节炎; 软骨下骨; 成骨细胞; 软骨; 软骨细胞;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

骨性关节炎是一种骨组织代谢疾病,软骨下骨成骨细胞直接参与骨性关节炎的病理过程。成骨细胞表达异常的生物学表型与软骨下骨结构和功能改变密切相关,其可使软骨承受更高的应力;软骨下骨成骨细胞产生的代谢调节因子通过骨和软骨间微结构直接促进软骨细胞退变。免疫和脂类代谢通过成骨细胞调节骨组织代谢,参与骨性关节炎病变过程。进一步阐明软骨下骨成骨细胞在骨性关节炎病变过程中的作用和机制,可为骨性关节炎研究和治疗提供新方法和思路。

引用

收藏

页码：167 / 172

页数：6

相关论文

共 16 条

[1]

Expression of vascular endothelial growth factor in normal, osteoarthritic and osteoporotic osteoblasts [J].

Corrado, Addolorata ;

Neve, Anna ;

Cantatore, Francesco Paolo .

CLINICAL AND EXPERIMENTAL MEDICINE, 2013, 13 (01) :81-84

[2]

Lateral Patellar Facetectomy Had Improved Clinical Results in Patients With Patellar-Retaining Total Knee Arthroplasty [J].

Zhang, Li-Zhi ;

Zhang, Xian-Long ;

Jiang, Yao ;

Wang, Qi ;

Chen, Yun-Su ;

Shen, Hao .

JOURNAL OF ARTHROPLASTY, 2012, 27 (08) :1442-1447

[3]

Mechanical and biologic link between cartilage and subchondral bone in osteoarthritis [J].

Zhang, Li-Zhi ;

Zheng, Hong-Ai ;

Jiang, Yao ;

Tu, Yi-Hui ;

Jiang, Pei-Hong ;

Yang, An-Li .

ARTHRITIS CARE & RESEARCH, 2012, 64 (07) :960-967

[4]

Bone structural changes in osteoarthritis as a result of mechanoregulated bone adaptation: a modeling approach [J].

Cox, L. G. E. ;

van Rietbergen, B. ;

van Donkelaar, C. C. ;

Ito, K. .

OSTEOARTHRITIS AND CARTILAGE, 2011, 19 (06) :676-682

[5]

Osteoblastogenesis and Adipogenesis Are Higher in Osteoarthritic than in Osteoporotic Bone Tissue [J].

Dragojevic, Jana ;

Logar, Darja Bitenc ;

Komadina, Radko ;

Marc, Janja .

ARCHIVES OF MEDICAL RESEARCH, 2011, 42 (05) :392-397

[6]

The expression of RANKL and OPG in the various grades of osteoarthritic cartilage [J].

Upton, Angus R. ;

Holding, Christopher A. ;

Dharmapatni, Anak A. S. S. K. ;

Haynes, David R. .

RHEUMATOLOGY INTERNATIONAL, 2012, 32 (02) :535-540

[7]

ERK-1/2 and p38 in the Regulation of Hypertrophic Changes of Normal Articular Cartilage Chondrocytes Induced by Osteoarthritic Subchondral Osteoblasts [J].

Prasadam, Indira ;

van Gennip, Stijn ;

Friis, Thor ;

Shi, Wei ;

Crawford, Ross ;

Xiao, Yin .

ARTHRITIS AND RHEUMATISM, 2010, 62 (05) :1349-1360

[8]

Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system [J].

Lin, Yu-Yu ;

Tanaka, Nobuaki ;

Ohkuma, Satoru ;

Iwabuchi, Yasunori ;

Tanne, Yuki ;

Kamiya, Takashi ;

Kunimatsu, Ryo ;

Huang, Yu-Ching ;

Yoshioka, Motoko ;

Mitsuyoshi, Tomomi ;

Tanimoto, Kotaro ;

Tanaka, Eiji ;

Tanne, Kazuo .

EUROPEAN JOURNAL OF ORAL SCIENCES, 2010, 118 (02) :151-158

[9]

Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis [J].

Sakao, Kei ;

Takahashi, Kenji A. ;

Arai, Yuji ;

Saito, Masazumi ;

Honjo, Kuniaki ;

Hiraoka, Nobuyuki ;

Asada, Hidetsugu ;

Shin-Ya, Masaharu ;

Imanishi, Jiro ;

Mazda, Osam ;

Kubo, Toshikazu .

JOURNAL OF BONE AND MINERAL METABOLISM, 2009, 27 (04) :412-423

[10]

Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: Influence of osteotropic factors [J].

Tat, Steeve Kwan ;

Pelletier, Jean-Pierre ;

Lajeunesse, Daniel ;

Fahmi, Hassan ;

Duval, Nicolas ;

Martel-Pelletier, Johanne .

BONE, 2008, 43 (02) :284-291