脑出血患者急性期血清HMGB1、ENA-78和S100β蛋白水平的变化及依达拉奉的干预作用

被引：12

作者：

詹利英

凌芳

华梅

机构：

[1] 武汉市第五医院神经内科

来源：

卒中与神经疾病 | 2013年 / 20卷 / 05期

关键词：

依达拉奉; 脑出血; 高迁移率族蛋白-1(HMGB1); 中性粒细胞激活肽-78(ENA-78); S-100β蛋白;

D O I：

暂无

中图分类号：

R743.34 [脑出血];

学科分类号：

摘要：

目的观察急性脑出血患者血清HMGB1、ENA-78和S100β水平的变化,并探讨依达拉奉对脑出血的脑保护作用机制。方法采用随机、对照、单盲的前瞻性研究。将本院卒中单元中符合纳入标准的160例高血压性脑出血(ICH)患者按照随机数字法分为常规治疗组80例和依达拉奉组80例,将100例体检健康者作为对照组。常规治疗组采用西医常规治疗方法,依达拉奉组在此基础上加用自由基清除剂依达拉奉治疗,每日2次,连续给药14 d。常规治疗组和依达拉奉组均检测发病第1 d(治疗前)、第3 d、第7 d、第14d血清HMGB1、ENA-78和S100β蛋白水平;治疗前、治疗后1周、2周和3周神经功能缺损评分采用SSS评分和BI指数(ADL评分)评定。结果与对照组比较,发病后第1 d,依达拉奉组和常规治疗组患者血清HMGB1、ENA-78和S100β水平均明显升高(均P<0.01),且达峰值,继之出现缓慢下降。在发病后第14 d,依达拉奉组和常规治疗组三项指标仍高于对照组(P均<0.01),但在发病后第3 d、第7 d、第14 d依达拉奉组血清HMGB1、ENA-78和S100β水平均明显低于常规治疗组(P<0.01)。治疗后2周和3周依达拉奉组患者ADL、SSS评分均高于常规治疗组(P<0.01)。治疗前,脑出血患者血清S-100β蛋白水平与SSS、ADL评分均呈负相关(分别r=-0.968,r=-0.959,P均<0.01),血清HMGB1水平与ENA-78水平呈显著正相关(r=0.788,P<0.01)。结论血清S-100β水平可作为评估脑出血后脑损伤严重程度的血清学指标,血清HMGB1和ENA-78可能参与了脑出血后急性期炎性反应过程。依达拉奉具有减轻脑出血后继发炎症反应、保护脑细胞和提高患者神经功能的作用。

引用

页码：306 / 311

页数：6

共 21 条

[11] Edaravone reduces brain oedema and attenuates cell death after intracerebral haemorrhage in mice [J].

Zhou, Feng ;

Chen, Gao ;

Zhang, Jianmin .

BRAIN INJURY, 2009, 23 (04) :353-357

[12] Correlation of free radical level and apoptosis after intracerebral hemorrhage in rats [J].

Han N. ;

Ding S.-J. ;

Wu T. ;

Zhu Y.-L. .

Neuroscience Bulletin, 2008, 24 (6) :351-358

[13]

Enhanced ENA-78 and IL-8 Expression in Patients with Malignant Pancreatic Diseases[J] . Vilma Oliveira Frick,Claudia Rubie,Mathias Wagner,Stefan Graeber,Henner Grimm,Berit Kopp,Bettina M. Rau,Martin K. Schilling.Pancreatology . 2008 (4-5)

[14] Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model [J].

Hagiwara, Satoshi ;

Iwasaka, Hideo ;

Hasegawa, Akira ;

Koga, Hironori ;

Noguchi, Takayuki .

CRITICAL CARE MEDICINE, 2008, 36 (08) :2407-2413

[15] S100B as an additional prognostic marker in subarachnoid aneurysmal hemorrhage [J].

Sanchez-Pena, Paola ;

Pereira, Ana-Rosa ;

Sourour, Nader-Antoine ;

Biondi, Alessandra ;

Lejean, Lise ;

Colonne, Chantal ;

Boch, Anne-Laure ;

Al Hawari, Mossab ;

Abdennour, Lamine ;

Paybasset, Louis .

CRITICAL CARE MEDICINE, 2008, 36 (08) :2267-2273

[16]

A Neutrophil Elastase Inhibitor, Sivelestat, Reduces Lung Injury Following Endotoxin-Induced Shock in Rats by Inhibiting HMGB1[J] . Satoshi Hagiwara,Hideo Iwasaka,Kazumi Togo,Takayuki Noguchi.Inflammation . 2008 (4)

[17] Different angiogenic CXC chemokine levels in bronchoalveolar lavage fluid after interferon gamma-1b therapy in idiopathic pulmonary fibrosis patients [J].

Antoniou, Katerina M. ;

Tzanakis, Nikolaos ;

Tzortzaki, Eleni G. ;

Malagari, Katerina ;

Koutsopoulos, Anastassios V. ;

Alexandrakis, Michael ;

Wells, Athol U. ;

Siafakas, Nikolaos M. .

PULMONARY PHARMACOLOGY & THERAPEUTICS, 2008, 21 (06) :840-844

[18]

Cytokine gene polymorphisms and BALF cytokine levels in interstitial lung diseases[J] . Martina Vasakova,Martina Sterclova,Libor Kolesar,Antonij Slavcev,Petr Pohunek,Jan Sulc,Ilja Striz.Respiratory Medicine . 2008 (5)

[19]

Basal and cytokine-stimulated production of epithelial neutrophil activating peptide-78 (ENA-78) and interleukin-8 (IL-8) by cultured human endometrial epithelial and stromal cells[J] . Nick A. Bersinger,Fioravante Frischknecht,Robert N. Taylor,Michael D. Mueller.Fertility and Sterility . 2008 (5)

[20]

Serum S100B, brain edema, and hematoma formation in a rat model of collagenase-induced hemorrhagic stroke[J] . Yu Tanaka,Toshiyuki Marumo,Hiromi Shibuta,Tomohiro Omura,Shigeru Yoshida.Brain Research Bulletin . 2008 (4)

← 1 2 3 →