树突状细胞在银屑病发病中的作用

被引：10

作者：

陈云刘

何焱玲

机构：

[1] 首都医科大学附属北京朝阳医院皮肤科

来源：

中国皮肤性病学杂志 | 2018年 / 32卷 / 02期

关键词：

银屑病; 朗格汉斯细胞; 浆细胞样树突状细胞; 髓样树突状细胞;

D O I：

10.13735/j.cjdv.1001-7089.201608135

中图分类号：

R758.63 [牛皮癣（银屑病）];

学科分类号：

100227 [皮肤病学];

摘要：

树突状细胞(dendritic cells,DCs)是一种抗原呈递细胞,广泛分布于组织及器官中。在皮肤中DCs主要包括朗格汉斯细胞(Langerhans cells,LCs)、浆细胞样树突状细胞(plasmacytoid dendritic cells,pDCs)及髓样树突状细胞(myeloid dendritic cells,mDCs)三种亚型。近年来随着对银屑病发病机制研究的深入,DCs在银屑病中的作用被大家所关注。pDCs在抗原刺激或应激下,通过分泌IFN-α启动银屑病;mDCs在抗原及IFN-α作用下成熟并迁移至淋巴结,通过抗原提呈及所分泌的细胞因子,促进T细胞增殖、分化及迁移,参与银屑病的进展。

引用

收藏

页码：223 / 226

页数：4

相关论文

共 7 条

[1]

T cell responses in psoriasis and psoriatic arthritis [J].

Diani, Marco ;

Altomare, Gianfranco ;

Reali, Eva .

AUTOIMMUNITY REVIEWS, 2015, 14 (04) :286-292

[2]

Specific roles for dendritic cell subsets during initiation and progression of psoriasis [J].

Glitzner, Elisabeth ;

Korosec, Ana ;

Brunner, Patrick M. ;

Drobits, Barbara ;

Amberg, Nicole ;

Schonthaler, Helia B. ;

Kopp, Tamara ;

Wagner, Erwin F. ;

Stingl, Georg ;

Holcmann, Martin ;

Sibilia, Maria .

EMBO MOLECULAR MEDICINE, 2014, 6 (10) :1312-1327

[3]

Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases [J].

Pablo Mackern-Oberti, Juan ;

Llanos, Carolina ;

Vega, Fabian ;

Salazar-Onfray, Flavio ;

Riedel, Claudia A. ;

Bueno, Susan M. ;

Kalergis, Alexis M. .

AUTOIMMUNITY REVIEWS, 2015, 14 (02) :127-139

[4]

Mechanism of pathogenesis of imiquimod-induced skin inflammation in the mouse: A role for interferon-alpha in dendritic cell activation by imiquimod [J].

Ueyama, Azumi ;

Yamamoto, Mina ;

Tsujii, Kenichiro ;

Furue, Yoko ;

Imura, Chihiro ;

Shichijo, Michitaka ;

Yasui, Kiyoshi .

JOURNAL OF DERMATOLOGY, 2014, 41 (02) :135-143

[5]

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses [J].

Lowes, Michelle A. ;

Russell, Chris B. ;

Martin, David A. ;

Towne, Jennifer E. ;

Krueger, James G. .

TRENDS IN IMMUNOLOGY, 2013, 34 (04) :174-181

[6]

CpG oligonucleotides induce the differentiation of CD4+Th17 cells by triggering plasmacytoid dendritic cells in adoptively cell transfer immunotherapy [J].

Xu, Lin ;

Wang, Chunhong ;

Zhou, Ya ;

Ren, Tao ;

Wen, Zhenke .

IMMUNOLOGY LETTERS, 2012, 142 (1-2) :55-63

[7]

Dendritic cells and immunity to Listeria:: TiPDCs are a new recruit [J].

Tam, MA ;

Wick, MJ .

TRENDS IN IMMUNOLOGY, 2004, 25 (07) :335-339