电针对创伤后应激障碍大鼠行为学和海马糖皮质激素受体表达的影响

被引:14
作者
侯良芹
刘嵩
熊克仁
机构
[1] 皖南医学院人体解剖学教研室
基金
安徽省自然科学基金;
关键词
创伤后应激障碍; 电针; 海马; 糖皮质激素受体; 盐皮质激素受体; 学习记忆能力;
D O I
10.13702/j.1000-0607.2013.02.010
中图分类号
R245 [针灸学、针灸疗法];
学科分类号
100512 ;
摘要
目的:观察电针对创伤后应激障碍(PTSD)模型大鼠的治疗作用并探讨其可能的作用机制,为临床针灸治疗PTSD提供依据。方法:SD大鼠随机分为正常组、模型组和电针组,每组10只。采用国际上公认的单程长时应激方法制作PTSD模型。电针组大鼠给予"百会"与"足三里"2Hz电针刺激,30min/次,每日治疗1次,连续1周。通过Morris水迷宫实验观察3组大鼠的学习记忆能力;采用免疫组织化学方法检测糖皮质激素受体(GR)和盐皮质激素受体(MR)在各组大鼠海马的表达。结果:模型大鼠的逃避潜伏期明显延长,电针治疗能显著缩短PTSD模型大鼠的逃避潜伏期(均P<0.05);模型组大鼠海马GR表达明显高于正常组,电针组大鼠海马GR表达显著低于模型组(均P<0.05);模型组大鼠海马MR表达明显低于正常组,电针组大鼠海马MR表达显著高于模型组(均P<0.05)。结论:电针改善PTSD模型大鼠空间学习记忆能力可能与电针影响其海马MR和GR的表达有关。
引用
收藏
页码:140 / 145
页数:6
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