克伦特罗检测方法进展

被引：10

作者：

黄传峰

李晓华

吴宜群

机构：

[1] 中国预防医学科学院中毒控制中心检测部,中国预防医学科学院中毒控制中心检测部,中国预防医学科学院中毒控制中心检测部,,

来源：

中国卫生检验杂志 | 2002年 / 05期

关键词：

克伦特罗; 尿样; 克仑特罗; 免疫亲和色谱; 检测方法;

D O I：

暂无

中图分类号：

R115 [卫生检验];

学科分类号：

摘要：

<正>克伦特罗作为β-2受体激动剂,最初主要用于人类哮喘和动物肺部疾病,又称氨哮素、双氯醇胺。在剂量较大时,可以引起头晕、心悸、手指震颤等副作用。由于克仑特罗具有蛋白同化作用,且与会成代谢类固醇不同之处在于其具有更高的选择性,可以减少脂肪的形成,提高瘦肉和脂肪的比率,故又称瘦肉精,因而被滥用于肉禽饲养业,造成该药在肉禽体内蓄积,尤其是肝脏组织中的浓度较高。人类食用含有克伦特罗的肉后会出现头晕、心悸、手指震颤等中毒症状[1],我国已有多次报道,已成为重大的食品安全问题。同时由于克仑特罗的促蛋白同化作用及其可以兴奋中枢神经系统而被非法用于体育运动,提高成绩,已被国际奥委会列为禁药。

引用

页码：634 / 636+563 +563

页数：4

共 9 条

[1]

Use of molecularly imprinted solid-phase extraction for the selective clean-up of clenbuterol from calf urine[J] . Christine Berggren,Sami Bayoudh,David Sherrington,Kees Ensing.Journal of Chromatography A . 2000 (1)

[2]

On-line coupling of solid-phase extraction with mass spectrometry for the analysis of biological samples[J] . C.H.P Bruins,C.M Jeronimus-Stratingh,K Ensing,W.D van Dongen,G.J de Jong.Journal of Chromatography A . 1999 (1)

[3] Solid phase extraction of clenbuterol from plasma using immunoaffinity followed by HPLC [J].

Rashid, BA ;

Kwasowski, P ;

Stevenson, D .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1999, 21 (03) :635-639

[4]

Long-term detection of clenbuterol in human scalp hair by gas chromatography–high-resolution mass spectrometry[J] . Journal of Chromatography B: Biomedical Sciences and Applications . 1999 (1)

[5]

β 2 -Adrenergic agonist residues: simultaneous methyl- and butylboronic derivatization for confirmatory analysis by gas chromatography–mass spectrometry[J] . Fernando Ramos,Cristina Santos,Antonieta Silva,Maria Irene Noronha da Silveira.Journal of Chromatography B: Biomedical Sciences and Applications . 1998 (1)

[6]

Detection of illegal clenbuterol use in calves using hair analysis[J] . Journal of Chromatography B: Biomedical Sciences and Applications . 1997 (1)

[7]

clenbuterol in the horse: confirmationand quantitation of serum clenbuterol by LC - MS -MS after oral intraacheal administration. A. F. Lehner, J. D. Harking, W. Karpiesiuk et al. Journal of analytical toxicology, 25 . 2001

[8]

Clinical and pharmacological profile in a clenbuterol epidemic poisoning of contaminated beef meat in Italy. Gianftanco Brambilk,Roberto Angeletti,Pietro Traldi et al. Toxicology letteral . 2000

[9]

Hogendoom.Piet van Zoonen.The potential of restricted access media cohjmns as applied in coupled in coupled - column LC/LC - TSP/ MS/MS for the highspeed determination of target compounds in serum. Application to the direct trace analysis o salbutamol and. Hbert A. Analytical Chemistry . 1998

← 1 →