强制性运动疗法对脑缺血后神经元轴突再生及Nogo-A蛋白水平影响的研究

被引：20

作者：

戚其学 ^{[1
]}

李玉芬 ^{[1
]}

赵珊珊 ^{[2
]}

聂莹雪 ^{[2
]}

赵传胜 ^{[2
]}

机构：

[1] 中国医科大学附属第一医院神经免疫室

[2] 中国医科大学附属第一医院神经内科

来源：

中国血液流变学杂志 | 2008年 / 03期

基金：

教育部留学回国人员科研启动基金;

关键词：

脑缺血; 强制性运动疗法; 轴突再生; Nogo-A;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

100204 [神经病学];

摘要：

目的探讨强制性运动疗法对脑缺血后神经元轴突再生及Nogo-A蛋白水平的影响。方法应用免疫组化及Western blot方法并结合行为学观察强制性运动疗法对脑缺血后神经元轴突再生及Nogo-A蛋白的表达的影响。结果脑缺血后强制性运动疗法能够促进患侧肢体运动功能的恢复,促进皮质脊髓束的再生,并能降低脑组织Nogo-A蛋白的表达水平。结论强制性运动疗法可能通过影响脑缺血后的神经再生过程从而增强中枢神经系统的修复能力。

引用

页码：317 / 319+340 +340

页数：4

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