丁苯肽胶囊对脑梗死患者血清MMP-9及TIMP-1的影响

被引：9

作者：

刘明伟 ^{[1
]}

陆爽 ^{[1
]}

郝丽 ^{[1
]}

林昕 ^{[1
]}

杨利荣 ^{[2
]}

曲艳 ^{[1
]}

张明谦 ^{[1
]}

机构：

[1] 云南省昆明市延安医院急诊科

[2] 云南省第一人民医院EICU

来源：

中华全科医学 | 2010年 / 8卷 / 02期

关键词：

dl-3-正丁基苯酞; 急性脑梗死; 基质金属蛋白酶-9; 基质金属蛋白酶抑制剂-1;

D O I：

10.16766/j.cnki.issn.1674-4152.2010.02.060

中图分类号：

R743.33 [脑栓塞];

学科分类号：

1002 ;

摘要：

目的探讨dl-3-正丁基苯酞软胶囊对急性脑梗死患者血清基质金属蛋白酶-9(MMP-9)及基质金属蛋白酶抑制剂-1(TIMP-1)的影响并研究其作用机制。方法将40例急性脑梗死患者随机分成两组,A组(银杏达莫20ml,1次/d,连续14d,静脉点滴);B组使用dl-3-正丁基苯酞软胶囊每次口服200mg,3次/d,疗程为24d。同期选择非脑血管病患者20例作为对照组。检测治疗前和治疗后第7天患者血清MMP-9及TIMP-1浓度的变化,测定治疗前、治疗第30天的NIHSS评分,判定两组的疗效。结果在治疗第7天,B组的MMP-9浓度明显低于A组(P<0.01)。治疗第7天时,与A组相比,B组TIMP-1浓度升高明显(P<0.01)。B组治疗的有效率及显效率明显高于A组(P<0.05)。结论dl-3-正丁基苯酞软胶囊能够直接降低血清MMP-9的浓度,或通过调节TIMP-1来降低MMP-9水平,可能是其有效治疗急性脑梗死的机制之一。

引用

页码：183 / 184

页数：2

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