Different roles of matrix metalloproteinases-2 and-9 after human ischaemic stroke

被引：112

作者：

Lucivero, V. ^{[1
]}

Prontera, M. ^{[1
]}

Mezzapesa, D. M. ^{[1
]}

Petruzzellis, M. ^{[1
]}

Sancilio, M. ^{[1
]}

Tinelli, A. ^{[1
]}

Di Noia, D. ^{[1
]}

Ruggieri, M. ^{[1
]}

Federico, F. ^{[1
]}

机构：

[1] Univ Bari, Dept Neurol & Psychiat Sci, I-70124 Bari, Italy

来源：

NEUROLOGICAL SCIENCES | 2007年 / 28卷 / 04期

关键词：

matrix metalloproteinases; acute ischaemic stroke;

D O I：

10.1007/s10072-007-0814-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Accumulating data suggest that matrix metalloproteinases (MMPs), in particular MMP-2 and MMP-9, are deleterious after acute ischaemic stroke. A beneficial effect of MMPs in the repairing phases of cerebral ischaemia has also been proposed. This study investigated the relationship between MMP-2 and MMP-9 and stroke subtypes, clinical recovery and haemorrhagic transformation (HT). We measured MMP-9 and MMP-2 plasma levels in 29 patients with ischaemic stroke at days one and seven. MMP-2 levels increased only in lacunar strokes, whilst MMP-9 increased only in patients with more severe stroke. Basal MMP-2 levels were higher in patients with stable or recovering symptoms whilst MMP-9 values at day seven were correlated with worse clinical outcome. No differences related to the presence of HT were found. This study sustains a different behaviour of MMPs after ischaemic stroke. MMP-2 seems to be expressed early and related to better outcome, whilst MMP-9 seems to be late and related to more severe stroke.

引用

页码：165 / 170

页数：6

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