吴茱萸次碱对心脏过敏损伤的保护作用

被引：6

作者：

易宏辉

让蔚清

谭桂山

徐康平

刘桂珍

李元建

机构：

[1] 中南大学约学院药理学系

[2] 中南大学药学院药物化学系

[3] 中南大学药学院药理学系

[4] 中南大学药学院药理学系长沙

[5] 长沙

来源：

中南药学 | 2003年 / 05期

关键词：

心脏过敏; 降钙素基因相关肽(CGRP); 吴茱萸次减; TNF-α; 豚鼠;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

目的观察吴茱萸次碱对心脏过敏损伤的保护作用与激活辣椒素受体。剌激内源性降钙素基因相关肽(CGRP)释放的关系。方法预致敏的离体心脏用K-H液恒压逆行灌流,从侧管中注入牛血清白蛋白(5 mg),造成过敏损伤。测定冠脉流出液中CGRP和心肌组织中肿瘤坏死因子(TNF-α)的浓度。结果预致敏的豚鼠心脏受抗原(牛血清蛋白)攻击引起冠脉流量(CF)显著减少,左室内压(LVP)和左室内压最大变化速率(±dp/dtmax)降低,同时伴有心率(HR)的增加和P-R间期的延长。两个浓度吴莱萸次碱(0.3或1.0 μmol·L-1)均能显著抑制抗原攻击所致的心功能抑制,表现为LVP、±dp/dtmax和CF升高,P-R间期明显缩短,并能同时促进CGRP的释放和降低心肌组织TNF-α的浓度。昊茱萸次碱对窦性心动过速无明显影响。吴茱萸次碱对心脏过敏损伤的保护作用能被一种选择性CGRP受体拮抗剂CGRP8-37所取消。结论吴茱萸次碱对心脏过敏损伤的保护作用是通过促进CGRP释放所介导,其心脏保护作用可能与抑制心肌组织TNF-α产生有关。

引用

页码：262 / 265

页数：4

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