Protective effects of calcitonin gene-related peptide-mediated evodiamine on guinea-pig cardiac anaphylaxis

被引:39
作者
Rang, WQ [1 ]
Du, YH [1 ]
Hu, CP [1 ]
Ye, F [1 ]
Tan, GS [1 ]
Deng, HW [1 ]
Li, YJ [1 ]
机构
[1] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Hunan, Peoples R China
关键词
cardiac anaphylaxis; calcitonin gene-related peptide; evodiamine; guinea-pig;
D O I
10.1007/s00210-002-0677-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Previous investigations have indicated that the pharmacological effects of evodiamine, a major alkaloidal component of the dried, unripe fruit of Evodia rutaecarpa Bentham (Rutaceae), are associated with stimulation of calcitonin gene-related peptide (CGRP) release and CGRP prevents cardiac anaphylactic injury. In the present study, the protective effects of evodiamine on cardiac anaphylaxis were examined. Presensitized guinea-pig hearts challenged with specific antigen (bovine serum albumin) caused a marked decrease in coronary flow, left ventricular pressure and its derivatives (+/-dp/dt(max)), an increase in heart rate, and prolongation of P-R interval. Evodiamine (0.3 muM or 1 muM) markedly increased the content of CGRP in the coronary effluent concomitantly with a significant improvement of cardiac function and alleviation of the extension of P-R interval. Evodiamine at the concentration of 1 muM also inhibited the sinus tachycardia. The protective effect of evodiamine on cardiac anaphylaxis was abolished by CGRP(8-37), the selective CGRP receptor antagonist. These results suggest that evodiamine possesses a protective effect of cardiac anaphylactic injury and that the effect of evodiamine is related to stimulation of CGRP release.
引用
收藏
页码:306 / 311
页数:6
相关论文
共 38 条
  • [1] Abend Y, 1996, J Basic Clin Physiol Pharmacol, V7, P57
  • [2] HEART AS A TARGET ORGAN IN SYSTEMIC ALLERGIC REACTIONS - COMPARISON OF CARDIAC ANAPHYLAXIS INVIVO AND INVITRO
    CAPURRO, N
    LEVI, R
    [J]. CIRCULATION RESEARCH, 1975, 36 (04) : 520 - 528
  • [3] THE VASORELAXANT EFFECT OF EVODIAMINE IN RAT ISOLATED MESENTERIC-ARTERIES - MODE OF ACTION
    CHIOU, WF
    CHOU, CJ
    SHUM, AYC
    CHEN, CF
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 215 (2-3) : 277 - 283
  • [4] Comparative study on the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa
    Chiou, WF
    Liao, JF
    Chen, CF
    [J]. JOURNAL OF NATURAL PRODUCTS, 1996, 59 (04): : 374 - 378
  • [5] COOPER DJ, 1992, ACP-APPL CARDIOPUL P, V5, P9
  • [6] Protective effects of calcitonin gene-related peptide on guinea-pig cardiac anaphylaxis
    Dai, W
    Zhou, FW
    Song, QJ
    Li, YJ
    Deng, HW
    Xiong, XM
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2000, 361 (02) : 161 - 165
  • [7] ENDOU M, 1994, J PHARMACOL EXP THER, V269, P221
  • [8] THE ROLE OF HISTAMINE IN CARDIAC ANAPHYLAXIS - CHARACTERIZATION OF HISTAMINERGIC H1-RECEPTOR AND H2-RECEPTOR EFFECTS
    FELIX, SB
    BAUMANN, G
    HELMUS, S
    SATTELBERGER, U
    [J]. BASIC RESEARCH IN CARDIOLOGY, 1988, 83 (05) : 531 - 539
  • [9] GIBSON SJ, 1984, J NEUROSCI, V4, P3101, DOI 10.1523/jneurosci.04-12-03101.1984
  • [10] EFFECT OF ADENOSINE ON HISTAMINE-RELEASE AND ATRIOVENTRICULAR-CONDUCTION DURING GUINEA-PIG CARDIAC ANAPHYLAXIS
    HELLER, LJ
    REGAL, JF
    [J]. CIRCULATION RESEARCH, 1988, 62 (06) : 1147 - 1158