髓系抑制细胞在1型糖尿病患者中作用的研究

被引：4

作者：

范冬晓 ^{[1
]}

杨巍 ^{[2
]}

机构：

[1] 吉林大学白求恩医学部临床医学系

[2] 吉林大学基础医学院免疫学系

来源：

微生物学免疫学进展 | 2019年 / 47卷 / 04期

关键词：

髓系抑制细胞; 1型糖尿病; 自身免疫性疾病;

D O I：

10.13309/j.cnki.pmi.2019.04.015

中图分类号：

R587.1 [糖尿病];

学科分类号：

100201 [内科学];

摘要：

髓系抑制细胞(myeloid-derived suppressor cells, MDSC)是来源于髓系的一类未成熟细胞群,初期对肿瘤的研究中发现,这类细胞具有抑制免疫应答,并促进炎性细胞因子及趋化因子分泌的作用,近年来对这类细胞在治疗自身免疫性疾病等方面的作用进行了研究。发现MDSC具有治疗自身免疫性疾病的功效;但也有研究显示,MDSC不仅无治疗效果,甚至还会起到相反的作用,这可能与其促炎因子过度分泌或诱导辅助性T细胞17(T helper cell, Th17)分化有关。1型糖尿病(type 1 diabetes, T1D)是一种常见的自身免疫性疾病,如何有效治疗该疾病一直是内分泌研究领域的热点。现就MDSC的来源、功能及其在T1D中的作用进行阐述,旨在为T1D的治疗提供新思路。

引用

页码：80 / 84

页数：5

共 17 条

[1]

The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process.[J].Antero Salminen;Kai Kaarniranta;Anu Kauppinen.Ageing Research Reviews.2018,

[2]

Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment [J].

Ostrand-Rosenberg, Suzanne ;

Fenselau, Catherine .

JOURNAL OF IMMUNOLOGY, 2018, 200 (02) :422-431

[3]

Phenotypic and Functional Diversities of Myeloid-Derived Suppressor Cells in Autoimmune Diseases.[J].Huijuan Ma;Chang-Qing Xia;Qingdong Guan.Mediators of Inflammation.2018,

[4]

Expression of checkpoint molecules on myeloid-derived suppressor cells.[J].Marlene Ballbach;Angelika Dannert;Anurag Singh;Darina M. Siegmund;Rupert Handgretinger;Luca Piali;Nikolaus Rieber;Dominik Hartl.Immunology Letters.2017,

[5]

Myeloid-derived suppressor cells mediate tolerance induction in autoimmune disease [J].

Wegner, Anja ;

Verhagen, Johan ;

Wraith, David C. .

IMMUNOLOGY, 2017, 151 (01) :26-42

[6]

Myeloid-Derived Suppressor Cells Are Controlled by Regulatory T Cells via TGF-β during Murine Colitis [J].

Lee, Cho-Rong ;

Kwak, Yewon ;

Yang, Taewoo ;

Han, Jung Hyun ;

Park, Sang-Heon ;

Ye, Michael B. ;

Lee, Wongeun ;

Sim, Kyu-Young ;

Kang, Jung-Ah ;

Kim, Yong-Chul ;

Mazmanian, Sarkis K. ;

Park, Sung-Gyoo .

CELL REPORTS, 2016, 17 (12) :3219-3232

[7]

Suppression of T cells by myeloid-derived suppressor cells in cancer.[J].Jieying Chen;Yingnan Ye;Pengpeng Liu;Wenwen Yu;Feng Wei;Hui Li;Jinpu Yu.Human Immunology.2016, 2

[8]

Myeloid-derived suppressor cells have a proinflammatory role in the pathogenesis of autoimmune arthritis [J].