Myeloid-Derived Suppressor Cells Are Controlled by Regulatory T Cells via TGF-β during Murine Colitis

被引：140

作者：

Lee, Cho-Rong ^{[1
]}

Kwak, Yewon ^{[1
]}

Yang, Taewoo ^{[1
]}

Han, Jung Hyun ^{[2
]}

Park, Sang-Heon ^{[1
]}

Ye, Michael B. ^{[3
]}

Lee, Wongeun ^{[1
]}

Sim, Kyu-Young ^{[1
]}

Kang, Jung-Ah ^{[1
]}

Kim, Yong-Chul ^{[1
,2
]}

Mazmanian, Sarkis K. ^{[4
]}

Park, Sung-Gyoo ^{[1
,2
]}

机构：

[1] Gwangju Inst Sci & Technol, Sch Life Sci, Gwangju 61005, South Korea

[2] Gwangju Inst Sci & Technol, Dept Biomed Sci & Engn, Gwangju 61005, South Korea

[3] Gwangju Inst Sci & Technol, Sch Liberal Arts & Sci, Gwangju 61005, South Korea

[4] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA

来源：

CELL REPORTS | 2016年 / 17卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

INFLAMMATORY-BOWEL-DISEASE; TOLERANCE; EXPANSION; SUBSETS; PROMOTE; MEDIATE; CANCER;

D O I：

10.1016/j.celrep.2016.11.062

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Myeloid-derived suppressor cells (MDSCs) are well known regulators of regulatory T cells (Treg cells); however, the direct regulation of MDSCs by Treg cells has not been well characterized. We find that colitis caused by functional deficiency of Treg cells leads to altered expansion and reduced function of MDSCs. During differentiation of MDSCs in vitro from bone marrow cells, Treg cells enhanced MDSC function and controlled their differentiation through a mechanism involving transforming growth factor-beta (TGF-beta). TGF-beta-deficient Treg cells were not able to regulate MDSC function in an experimentally induced model of colitis. Finally, we evaluated the therapeutic effect of TGF-beta-mediated in-vitro-differentiated MDSCs on colitis. Adoptive transfer of MDSCs that differentiated with TGF-beta led to better colitis prevention than the transfer of MDSCs that differentiated without TGF-beta. Our results demonstrate an interaction between Treg cells and MDSCs that contributes to the regulation of MDSC proliferation and the acquisition of immunosuppressive functions.

引用

页码：3219 / 3232

页数：14

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