肺泡巨噬细胞及其相关细胞因子与慢性阻塞性肺疾病相互关系研究进展

被引：19

作者：

常嘉琛

焦宗宪

机构：

[1] 兰州大学基础医学院病理学研究所

来源：

国际呼吸杂志 | 2012年 / 21期

基金：

教育部留学回国人员科研启动基金;

关键词：

慢性阻塞性肺疾病; 香烟烟雾; 巨噬细胞; 炎症;

D O I：

暂无

中图分类号：

R563.9 [其他];

学科分类号：

100201 [内科学];

摘要：

慢性阻塞性肺疾病(COPD)的特点是肺脏在内、外界环境中各种有害因子的刺激下表现出的异常炎症反应,吸烟是COPD的主要危险因素。巨噬细胞在COPD炎症反应和慢性支气管炎的发病中起着关键作用,在气道、肺实质、支气管肺泡灌洗液以及痰液中数量明显增多,此外,在气道中巨噬细胞数量与COPD严重程度存在一定的相关性。在COPD疾病进展中,巨噬细胞产生并释放炎症介质,细胞因子如IL-8、IL-6、TNF-α以及MMP-9、MMP-12等促进炎症的发生、发展最终破坏肺组织引起不可逆性气流受限。

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