天然黄酮类化合物及其衍生物的构效关系研究进展

被引：53

作者：

钟建青 ^{[1
]}

李波 ^{[2
]}

贾琦 ^{[1
]}

李医明 ^{[1
]}

朱维良 ^{[2
]}

陈凯先 ^{[1
,2
]}

机构：

[1] 上海中医药大学中药学院

[2] 中国科学院上海药物研究所药物发现与设计中心

来源：

药学学报 | 2011年 / 06期

关键词：

黄酮类化合物; 衍生物; 构效关系;

D O I：

10.16438/j.0513-4870.2011.06.004

中图分类号：

R284.1 [化学分析与鉴定];

学科分类号：

摘要：

天然黄酮类化合物是广泛分布于自然界的一大类化合物,已有文献报道其具有抗癌、抗氧化、抗炎、保肝、抗血栓形成、舒张血管、抗病毒、抗菌和抗过敏等多种药理活性。但该类化合物因溶解度差、生物利用度不高等自身缺点而限制了临床上的广泛应用。目前国内外许多课题组选择以天然黄酮为研究对象,通过结构改造研究其针对不同生理活性的构效关系,力求克服其自身缺点,开发出一批具有新颖结构的黄酮类药物的先导化合物。本文总结分析了近几年该类化合物构效关系的研究进展,期望为黄酮类衍生物的设计合成提供参考。

引用

页码：622 / 630

页数：9

共 17 条

[1] Bioavailability of dietary flavonoids and phenolic compounds [J].

Crozier, Alan ;

Del Rio, Daniele ;

Clifford, Michael N. .

MOLECULAR ASPECTS OF MEDICINE, 2010, 31 (06) :446-467

[2] Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism [J].

Anso, Elena ;

Zuazo, Alicia ;

Irigoyen, Marta ;

Urdaci, Maria C. ;

Rouzaut, Ana ;

Martinez-Irujo, Juan J. .

BIOCHEMICAL PHARMACOLOGY, 2010, 79 (11) :1600-1609

[3]

Plant extracts with anti-inflammatory properties—A new approach for characterization of their bioactive compounds and establishment of structure–antioxidant activity relationships[J] . Sónia Amaral,Lurdes Mira,J.M.F. Nogueira,Alda Pereira da Silva,M. Helena Florêncio.Bioorganic ＆ Medicinal Chemistry . 2009 (5)

[4] Structural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition [J].

Ryu, Young Bae ;

Curtis-Long, Marcus J. ;

Lee, Ji Won ;

Ryu, Hyung Won ;

Kim, Jun Young ;

Lee, Woo Song ;

Park, Ki Hun .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (17) :4912-4915

[5]

The effects of twelve representative flavonoids on tissue factor expression in human monocytes: Structure-activity relationships[J] . Wenwen Jiang,Junping Kou,Zhi Zhang,Boyang Yu.Thrombosis Research . 2009 (6)

[6]

Structure–activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities[J] . Ai-Lin Liu,Hai-Di Wang,Simon MingYuen Lee,Yi-Tao Wang,Guan-Hua Du.Bioorganic ＆ Medicinal Chemistry . 2008 (15)

[7]

Structure–activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects[J] . Ryoko Takasawa,Saki Takahashi,Kazunori Saeki,Satoshi Sunaga,Atsushi Yoshimori,Sei-ichi Tanuma.Bioorganic ＆ Medicinal Chemistry . 2008 (7)

[8]

Effect of flavonoids on rat splenocytes, a structure–activity relationship study[J] . Rocío López-Posadas,Isabel Ballester,Ana Clara Abadía-Molina,María Dolores Suárez,Antonio Zarzuelo,Olga Martínez-Augustin,Fermín Sánchez de Medina.Biochemical Pharmacology . 2008 (4)

[9]

Structure–activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2[J] . Yesseny Vasquez-Martinez,Rachana V. Ohri,Victor Kenyon,Theodore R. Holman,Silvia Sepúlveda-Boza.Bioorganic ＆ Medicinal Chemistry . 2007 (23)

[10] Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase [J].

Holder, Sheldon ;

Lilly, Michael ;

Brown, Milton L. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (19) :6463-6473

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