帕金森病患者血清炎症因子水平及其临床意义

被引：14

作者：

王叶冉

刘雨辉

梁春荣

姚秀卿

王延江

机构：

[1] 第三军医大学大坪医院野战外科研究所神经内科

来源：

重庆医学 | 2014年 / 43卷 / 15期

关键词：

帕金森病; 白细胞介素1β; 白细胞介素6; 肿瘤坏死因子α; 干扰素Ⅱ型;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

摘要：

目的探讨帕金森病(PD)患者血清中主要炎症因子IL-1β、IL-6、肿瘤坏死因子α(TNF-α)和干扰素γ(IFN-γ)水平的变化及其与病程、疾病严重程度的相关性。方法采集56例PD患者及120例健康者(对照组)的血液样本,采用ELISA检测血清中的IL-1β、IL-6、TNF-α和IFN-γ的水平。结果 PD患者血清IL-1β、IL-6及TNF-α水平显著高于对照组(P<0.01),血清IFN-γ水平差异无统计学意义(P=0.86)。PD患者血清炎症因子水平与病程、Hoen&Yahr分期、Schwab&England日常活动分级评分均无相关性(P>0.05)。结论炎症参与了PD的病理过程,血清炎症因子与病程和疾病严重程度均无相关性。

引用

页码：1848 / 1850

页数：3

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