面向代谢组学的模式识别技术应用与展望

被引：26

作者：

宋凯

李霞

机构：

[1] 天津大学化工学院

来源：

生物信息学 | 2008年 / 02期

关键词：

代谢组学; 模式识别; 系统生物学; 数据预处理;

D O I：

暂无

中图分类号：

Q591 [物质代谢及能量代谢];

学科分类号：

070307 [化学生物学];

摘要：

代谢组学是后基因时代新兴的一门研究生物体内所有小分子代谢物的组学学科,是系统生物学的有机组成部分。由于代谢组学是基于数据驱动的学科,因此如何有效利用数据预处理、模式识别等信息处理技术从代谢组学复杂的高维样本中挖掘深层次的"知识"是代谢组学乃至整个系统生物学的关键问题。对模式识别技术在代谢组学中的应用作了全面的综述。总结代谢组学数据特性及其对模式识别技术的特殊要求,揭示面向代谢组学的模式识别技术所遇到的困难并在此基础上提出相应的解决办法。

引用

页码：90 / 92+96 +96

页数：4

共 13 条

[1]

Metabolomics, genomics, proteomics, and the identification of enzymes and their substrates and products [J].

Fridman, E ;

Pichersky, E .

CURRENT OPINION IN PLANT BIOLOGY, 2005, 8 (03) :242-248

[2]

Metabolomics in practice: Emerging knowledge to guide future dietetic advice toward individualized health [J].

German, JB ;

Watkins, SM ;

Fay, LB .

JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION, 2005, 105 (09) :1425-1432

[3]

A metabolome pipeline: from concept to data to knowledge [J].

Brown, Marie ;

Dunn, Warwick B. ;

Ellis, David I. ;

Goodacre, Royston ;

Handl, Julia ;

Knowles, Joshua D. ;

O'Hagan, Steve ;

Spasic, Irena ;

Kell, Douglas B. .

METABOLOMICS, 2005, 1 (01) :39-51

[4]

Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis [J].

Lindon, JC ;

Holmes, E ;

Bollard, ME ;

Stanley, EG ;

Nicholson, JK .

BIOMARKERS, 2004, 9 (01) :1-31

[5]

Contemporary issues in toxicology - The role of metabonomics in toxicology and its evaluation by the COMET project [J].

Lindon, JC ;

Nicholson, JK ;

Holmes, E ;

Antti, H ;

Bollard, ME ;

Keun, H ;

Beckonert, O ;

Ebbels, TM ;

Reilly, MD ;

Robertson, D ;

Stevens, GJ ;

Luke, P ;

Breau, AP ;

Cantor, GH ;

Bible, RH ;

Niederhauser, U ;

Senn, H ;

Schlotterbeck, G ;

Sidelmann, UG ;

Laursen, SM ;

Tymiak, A ;

Car, BD ;

Lehman-McKeeman, L ;

Colet, JM ;

Loukaci, A ;

Thomas, C .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2003, 187 (03) :137-146

[6]

NMR-based metabonomic toxicity classification: hierarchical cluster analysis and k-nearest-neighbour approaches.[J].Olaf Beckonert;Mary E. Bollard;Timothy M.D Ebbels;Hector C Keun;Henrik Antti;Elaine Holmes;John C Lindon;Jeremy K Nicholson.Analytica Chimica Acta.2003, 1

[7]

Metabolomics – the link between genotypes and phenotypes.[J].Oliver Fiehn.Plant Molecular Biology.2002, 1

[8]

Pattern recognition methods and applications in biomedical magnetic resonance [J].