阿尔茨海默氏病的流行病学、遗传学及其它(英文)

被引：19

作者：

王晓平 ^{[1
]}

丁洪流 ^{[2
]}

机构：

[1] 上海交通大学附属第一人民医院

[2] 美国麻省大学梅耶医学研究所

来源：

NeuroscienceBulletin | 2008年 / 02期

关键词：

阿尔茨海默氏病; β-淀粉样前体蛋白; 早老素; 载脂蛋白;

D O I：

暂无

中图分类号：

R749.1 [脑器质性精神障碍];

学科分类号：

100205 ;

摘要：

阿尔茨海默氏病是一种不断增长的威胁公众健康的流行疾患。男女两性均对此病易感,以女性稍甚。该病患病率在老年人群中呈指数上升,65岁时患病率约1%,至95岁时达到40%-50%。尽管病因尚未被完全了解,遗传因素已被确认在其发病中扮演重要角色。发生在三个基因(APP,PSEN1,PSEN2)中的突变可导致该病,而APOE4等位基因与患病的危险增加有关。随着人类基因组研究的进展,可能会有更多与该病相关的基因被发现。目前,应用遗传筛选测试,可以帮助阿尔茨海默氏病的高危人群更好地准备和应对未来可能发生的疾病。

引用

页码：105 / 109

页数：5

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