Association study of the ubiquilin gene with Alzheimer's disease

被引：26

作者：

Bensemain, Faiza

Chapuis, Julien

Tian, Jinzhou

Shi, Jing

Thaker, Uma

Lendon, Corinne

Iwatsubo, Takeshi

Amouyel, Philippe

Mann, David

Lambert, Jean-Charles

机构：

[1] Univ Lille 2, Inst Pasteur Lille, INSERM, U744, F-5019 Lille, France

[2] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Care Elderly, Beijing 100700, Peoples R China

[3] Hope Hosp, Greater Manchester Neurosci Ctr, Clin Neurosci Res Grp, Salford M6 8HD, Lancs, England

[4] Univ Birmingham, Queen Elizabeth Psychiat Hosp, Div Neurosci, Dept Mol Psychiat, Birmingham B15 2QZ, W Midlands, England

[5] Univ Tokyo, Dept Neuropathol & Neurosci, Tokyo 113, Japan

来源：

NEUROBIOLOGY OF DISEASE | 2006年 / 22卷 / 03期

关键词：

Alzheimer; ubiquilin; polymorphism; genetic determinant; splicing;

D O I：

10.1016/j.nbd.2006.01.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recently, the ubiquilin 1 gene has been proposed as a major candidate gene for AD. Here, we have investigated the potential impact of the UBQ-8i polymorphism (rs12344615) within this gene on the risk of developing AD. No association of this polymorphism with the disease was observed in a large French case-control population. Furthermore, no relationship between this polymorphism and A load or degree of neurofibrillary degeneration in the brains of 114 patients with AD was detected. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：691 / 693

页数：3

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