创伤性关节炎发生机制相关性研究

被引：35

作者：

刘洪

廖琦

郝亮

机构：

[1] 南昌大学第二附属医院骨科

来源：

国际骨科学杂志 | 2010年 / 31卷 / 01期

关键词：

创伤; 关节炎; 生物力学; 基因;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

创伤性关节炎发生机制研究显示,关节软骨凋亡或坏死引起关节软骨数量减少,导致关节软骨退变;关节生物力学及其关节周围环境应力改变引起关节软骨细胞及基质之间的动态平衡破坏,进一步引发关节软骨退变;关节损伤后关节液中细胞炎症介质对关节软骨的作用及介质之间相互作用在关节软骨退变中起着重要作用;关节损伤疾病发展过程及关节软骨代谢均与患者个体基因学关系密切。研究明确关节损伤后各种因素在创伤性关节炎中的作用及各种因素之间的联系,有助于更深入地了解创伤性关节炎的发生机制,更好地制定相关治疗方案,以治愈或延缓创伤性关节炎的发生发展。

引用

页码：39 / 41

页数：3

共 13 条

[1]

Quantifying tibial plafond fracture severity: Absorbed energy and fragment displacement agree with clinical rank ordering [J].

Anderson, Donald D. ;

Mosqueda, Teresa ;

ThomaS, Thaddeus ;

Hermanson, Evan L. ;

Brown, Thomas D. ;

Marsh, J. Lawrence .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2008, 26 (08) :1046-1052

[2]

Zonal changes in the three-dimensional morphology of the chondron under compression: The relationship among cellular, pericellular, and extracellular deformation in articular cartilage [J].

Choi, Jae Bong ;

Youn, Inchan ;

Cao, Li ;

Leddy, Holly A. ;

Gilchrist, Christopher L. ;

Setton, Lori A. ;

Guilak, Farshid .

JOURNAL OF BIOMECHANICS, 2007, 40 (12) :2596-2603

[3]

Catalytically active Yersinia outer protein P induces cleavage of RIP and caspase-8 at the level of the DISC independently of death receptors in dendritic cells [J].

Groebner, Sabine ;

Adkins, Irena ;

Schulz, Sebastian ;

Richter, Kathleen ;

Borgmann, Stefan ;

Wesselborg, Sebastian ;

Ruckdeschel, Klaus ;

Micheau, Olivier ;

Autenrieth, Ingo B. .

APOPTOSIS, 2007, 12 (10) :1813-1825

[4]

Cytokines, tumor necrosis factor-α and interleukin-1β, differentially regulate apoptosis in osteoarthritis cultured human chondrocytes [J].

Lopez-Armada, M. J. ;

Carames, B. ;

Lires-Dean, M. ;

Cillero-Pastor, B. ;

Ruiz-Romero, C. ;

Galdo, F. ;

Blanco, F. J. .

OSTEOARTHRITIS AND CARTILAGE, 2006, 14 (07) :660-669

[5]

The development of posttraumatic arthritis after articular fracture [J].

Furman, Bridgette D. ;

Olson, Steven A. ;

Guilak, Farshid .

JOURNAL OF ORTHOPAEDIC TRAUMA, 2006, 20 (10) :719-725

[6]

Pathomechanisms of cartilage destruction by mechanical injury.[J].Bodo Kurz;Angelika K. Lemke;Jakob Fay;Thomas Pufe;Alan J. Grodzinsky;Michael Schünke.Annals of Anatomy.2005, 5

[7]

Regeneration in MRL mice:: further genetic loci controlling the ear hole closure trait using MRL and M.m. Castaneus mice [J].