花生四烯酸代谢网络研究:从关键酶的单靶标抑制剂到多靶标抑制剂

被引：18

作者：

刘莹

陈政

尚尔昌

杨坤

位灯国

周璐

蒋小蕗

贺冲

来鲁华

机构：

[1] 北京大学化学与分子工程学院,北京分子科学国家实验室(筹),分子动态与稳态结构国家重点实验室

来源：

药学学报 | 2009年 / 03期

关键词：

花生四烯酸代谢网络; 关键酶; 单靶标抑制剂; 多靶标抑制剂;

D O I：

10.16438/j.0513-4870.2009.03.012

中图分类号：

R91 [药物基础科学];

学科分类号：

1007 ;

摘要：

炎症引发的疾病是人类常见的免疫系统疾病,医药市场对抗炎药物的需求量极大。花生四烯酸代谢网络是产生炎症介质的主要网络,网络中的一些蛋白质已成为抗炎药物设计的重要靶标,但这些单靶标药物不能很好地控制网络的平衡,同时容易引起副作用。大多数炎症引发的疾病是由多级联炎症代谢共同影响的结果,为了更好地治疗这类由多个药靶参与调控的复杂疾病,发展针对花生四烯酸代谢网络的多靶标药物具有迫切性。本文综述花生四烯酸代谢网络的关键靶标(如磷脂酶A2、环氧合酶、5-脂氧合酶和白三烯A4水解酶等)的特异性抑制剂和多靶标抑制剂研究进展。

引用

页码：231 / 241

页数：11

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