帕金森病动物模型研究进展

被引：7

作者：

张健

徐阿晶

机构：

[1] 上海交通大学医学院附属新华医院药学部

来源：

药学服务与研究 | 2012年 / 12卷 / 05期

关键词：

帕金森病; 动物模型; 神经毒素; 遗传基因; 综述;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

1002 ;

摘要：

帕金森病是老年期常见的慢性退行性疾病,其发病机制尚未明了,目前尚无有效根治或者逆转病情的药物。为了更好地了解帕金森病的病理机制并寻求更有效的治疗药物,建立帕金森病相关动物模型至关重要。目前常见的帕金森病动物模型有神经毒素模型、转基因模型和基因敲除模型,本文对此做一综述。

引用

页码：382 / 386

页数：5

共 11 条

[1] 农药百草枯致小鼠帕金森病模型研究附视频 [J].

张楠 ;

陈忻 ;

张思玉 .

脑与神经疾病杂志, 2008, (02) :120-122

[2] UCH-L1基因多态性与帕金森病的关联研究 [J].

肖颖 ;

张本恕 .

中华医学遗传学杂志, 2008, (05)

[3]

Behavioral and quantitative mitochondrial proteome analyses of the effects of simvastatin: implications for models of neural degeneration[J] . Ilse S. Pienaar,Timothy Schallert,Suzél Hattingh,William M. U. Daniels. Journal of Neural Transmission . 2009 (7)

[4] The familial parkinsonism gene LRRK2 regulates neurite process morphology [J].

MacLeod, David ;

Dowman, Julia ;

Hammond, Rachel ;

Leete, Thomas ;

Inoue, Keiichi ;

Abeliovich, Asa .

NEURON, 2006, 52 (04) :587-593

[5] Genetic analysis of Nurr1 haplotypes in Parkinson's disease [J].

Tan, EK ;

Chung, H ;

Zhao, Y ;

Shen, H ;

Chandran, VR ;

Tan, C ;

Teoh, ML ;

Yih, Y ;

Pavanni, R ;

Wong, MC .

NEUROSCIENCE LETTERS, 2003, 347 (03) :139-142

[6] The UCH-L1 gene encodes two opposing enzymatic activities that affect α-synuclein degradation and Parkinson's disease susceptibility [J].

Liu, YC ;

Fallon, L ;

Lashuel, HA ;

Liu, ZH ;

Lansbury, PT .

CELL, 2002, 111 (02) :209-218

[7]

C. elegans : a novel pharmacogenetic model to study Parkinson's disease[J] . R. Nass,D.M. Miller,R.D. Blakely. Parkinsonism and Related Disorders . 2001 (3)

[8] The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system [J].

Herrera, AJ ;

Castaño, A ;

Venero, JL ;

Cano, J ;

Machado, A .

NEUROBIOLOGY OF DISEASE, 2000, 7 (04) :429-447

[9]

C. elegans Locomotory Rate Is Modulated by the Environment through a Dopaminergic Pathway and by Experience through a Serotonergic Pathway[J] . Elizabeth R Sawin,Rajesh Ranganathan,H.Robert Horvitz. Neuron . 2000 (3)

[10]

Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways .2 Hasegawa T,Treis A,Patenge N,Fiesel FC,Springer W,Kahle PJ. J Neurochem . 2008

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