SREBPs信号转导途径与动脉粥样硬化研究进展

被引：3

作者：

李博

李卫华

机构：

[1] 厦门大学附属第一医院心血管内科

来源：

心血管病学进展 | 2011年 / 32卷 / 06期

关键词：

动脉粥样硬化; 固醇调节元件结合蛋白; 胆固醇;

D O I：

暂无

中图分类号：

R543.5 [动脉疾病];

学科分类号：

1002 ; 100201 ;

摘要：

固醇调节元件结合蛋白对细胞内胆固醇的稳态调节有重要作用,近几年研究发现固醇调节元件结合蛋白广泛参与了动脉粥样硬化危险因素如吸烟、高血糖、脂代谢障碍、肥胖、高血压等的促动脉粥样硬化作用,现就固醇调节元件结合蛋白在动脉粥样硬化中作用的最新进展做一综述,有助于对动脉粥样硬化的发病机理有更新、更全面的认识。

引用

页码：876 / 879

页数：4

共 19 条

[1] 动脉粥样硬化炎症信号转导通路研究进展 [J].

李玉洁 ;

杨庆 ;

翁小刚 ;

王怡薇 ;

朱晓新 .

中国药理学通报, 2009, (07) :857-860

[2]

Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease[J]. Masahide Hamaguchi,Takao Kojima,Noriyuki Takeda,Chisato Nagata,Jun Takeda,Hiroshi Sarui,Yutaka Kawahito,Naohisa Yoshida,Atsushi Suetsugu,Takahiro Kato,Junichi Okuda,Kazunori Ida,Toshikazu Yoshikawa.World Journal of Gastroenterology. 2007(10)

[3] 雷帕霉素洗脱支架在冠心病的临床疗效 [J].

李卫华 ;

吴荣 ;

谢强 ;

郭启军 ;

腾志超 ;

刘圣文 .

福建医科大学学报, 2004, (04) :451-452

[4]

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques[J] . Jing-Jie Tang,Jia-Gui Li,Wei Qi,Wen-Wei Qiu,Pei-Shan Li,Bo-Liang Li,Bao-Liang Song.Cell Metabolism . 2011 (1)

[5]

The Akt–SREBP nexus: cell signaling meets lipid metabolism[J] . James R. Krycer,Laura J. Sharpe,Winnie Luu,Andrew J. Brown.Trends in Endocrinology ＆ Metabolism . 2010 (5)

[6] Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes [J].

Kotzka, Jorg ;

Knebel, Birgit ;

Avci, Haluk ;

Jacob, Sylvia ;

Nitzgen, Ulrike ;

Jockenhovel, Friedrich ;

Heeren, Joerg ;

Haas, Jutta ;

Muller-Wieland, Dirk .

ATHEROSCLEROSIS, 2010, 213 (01) :156-165

[7] Static pressure accelerates ox-LDL-induced cholesterol accumulation via SREBP-1-mediated caveolin-1 downregulation in cultured vascular smooth muscle cells [J].

Luo, Di-xian ;

Xia, Cheng-lai ;

Li, Jun-mu ;

Xiong, Yan ;

Yuan, Hao-yu ;

Tang, Zhen-Wang ;

Zeng, Yixin ;

Liao, Duan-fang .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 403 (01) :52-58

[8] Sterol metabolism and SREBP activation [J].

Sato, Ryuichiro .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2010, 501 (02) :177-181

[9] Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1 [J].

Yuan, Hongwei ;

Shyy, John Y. -J. ;

Martins-Green, Manuela .

JOURNAL OF HEPATOLOGY, 2009, 51 (03) :535-547

[10]

Inflammatory stress increases unmodified LDL uptake via LDL receptor: an alternative pathway for macrophage foam-cell formation[J] . Qiang Ye,Yaxi Chen,Han Lei,Qing Liu,John F. Moorhead,Zac Varghese,Xiong Z. Ruan.Inflammation Research . 2009 (11)

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