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生物可降解5-氟尿嘧啶载药微球的制备及性能研究
被引：33
作者：
尹静波
陈红丹
罗坤
庄秀丽
陈学思
曹田
机构：
[1] 上海大学高分子材料系,上海大学高分子材料系,上海大学高分子材料系,中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,上海大学高分子材料系上海,上海,上海,长春,长春,上海
来源：
关键词：
5-氟尿嘧啶;
聚乳酸(PLA);
乳酸-乙二醇(PLA-PEG);
微球;
纳米二氧化硅;
控制药物释放;
D O I：
暂无
中图分类号：
TQ463.53 [];
学科分类号：
摘要：
Microspheres containing an antimetabolite drug 5-Fluorouracil were prepared from (poly(lactic) acide)(PLA) or poly(lactic acid)-polyethylene glycol(PLA-PEG) as the carrier by using a water-in-oil-in-water emulsion solvent evaporation technique. The conditions of the microspheres preparation such as polymer concentration in organic solvent, relative molecular weight of PLA-PEG and PLA/PEG mass ratio were discussed. The surface morphology and the size of the microspheres were observed by SEM. The drug content of microspheres was examined by TGA and the drug release in vitro was evaluated. According to the results, the drug content increased with the nano-silica used. The highest drug content in this study was 39.9%. The drug-release kinetics satisfied the requirements of controlled drug-release.
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页码：1174 / 1176
页数：3
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