谷胱甘肽硫-转移酶研究进展

被引:46
作者
聂立红
王声湧
胡毅玲
机构
[1] 暨南大学医学院第一附属医院内科!广东广州,暨南大学医学院流行病学教研室!广东广州,暨南大学医学院流行病学教研室!广东广州
关键词
谷胱甘肽转移酶类; 肿瘤; 分子结构;
D O I
暂无
中图分类号
R341 [];
学科分类号
1001 ;
摘要
Glutathione S-transferases(GSTs) are a family of soluble detoxification enzymes which use reduced glutathione(GSH) in conjugation and reduction reactions.Toxic electrophiles,including a variety of carcinogens,are substrates for the GSTs and are more easily excreted into bile or urine after conjugation or reduction .The three-dimensional structures of GSTs from several species,including humans,have been determined.GST activity has been found to present in all human tissues,and expression of the various GST isoenzymes differs in degree in the various tissues. Glutathione S-transferases may play a role in the protection of cells against toxic electrophiles and in the resistance to cancer chemotherapeutic agants.The polymorphisms of GSTs genes are one of the important factors that exercise influence on individual susceptibility to cancer.
引用
收藏
页码:89 / 92
页数:4
相关论文
共 25 条
[1]  
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Hayes JD,Pulford DJ. Critical Reviews in Biochemistry and Molecular Biology . 1995
[2]  
Environmental Health Perspectives[C]. 2010 the 5th International Academic Conference on Environmental and Occupational Medicine,2010
[3]  
Location of a potential transport binding site in a sigma class glutathione transferase by x- ray crystallography. Ji X,Von RE,Johnson WW,et al. Proceedings of the National Academy of Sciences of the United States of America . 1996
[4]  
Characterization of a chlorambucil-resistant human ovarian carcinoma cell line overexpressing glutathione S-transferase mu. Horton JK,Roy G,Piper JT,et al. Biochemical Pharmacology . 1999
[5]  
The ligandin(non - substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site(H site). Oakley AJ,Lo Bello M,Nuccetelli M,et al. Journal of Molecular Biology . 1999
[6]  
Identification of the nonsubstrate steroid binding site of rat liver glutathione S-transferase,isozyme 1 - 1, by the steroid affinity label, 3beta -(iodoacetoxy) dehydroisoandrosterone. Barycki JJ,Colman RF. Archive of Biochemistry and Biophysics . 1997
[7]  
Crystal structures of a schistosomal drug and vaccine target: glutathione S transferases from Schistosoma japonica and its complex with the leading antischistosomal drug praziquantel. McTigue MA,Williams DR,Tainer JA. Journal of Molecular Biology . 1995
[8]  
Purification, characterization and tissue distribution of human class theta glutathione S-transferase T1-1. Juronen E,Tasa M,Uuskula M,et al. Journal of Biochemistry and Molecular Biology . 1996
[9]  
Glutathione S-transferases in human liver cancer. Hayes PC,May L,Hayes JD,et al. Gut . 1991
[10]  
Characterization of glutathione S-transferase in cultured human keratinocytes. Blacker KL,Olson E,Vessey DA,et al. Journal of Investigative Dermatology . 1991