谷胱甘肽硫-转移酶研究进展

被引：46

作者：

聂立红

王声湧

胡毅玲

机构：

[1] 暨南大学医学院第一附属医院内科!广东广州,暨南大学医学院流行病学教研室!广东广州,暨南大学医学院流行病学教研室!广东广州

来源：

中国病理生理杂志 | 2000年 / 11期

关键词：

谷胱甘肽转移酶类; 肿瘤; 分子结构;

D O I：

暂无

中图分类号：

R341 [];

学科分类号：

1001 ;

摘要：

Glutathione S-transferases(GSTs) are a family of soluble detoxification enzymes which use reduced glutathione(GSH) in conjugation and reduction reactions.Toxic electrophiles,including a variety of carcinogens,are substrates for the GSTs and are more easily excreted into bile or urine after conjugation or reduction .The three-dimensional structures of GSTs from several species,including humans,have been determined.GST activity has been found to present in all human tissues,and expression of the various GST isoenzymes differs in degree in the various tissues. Glutathione S-transferases may play a role in the protection of cells against toxic electrophiles and in the resistance to cancer chemotherapeutic agants.The polymorphisms of GSTs genes are one of the important factors that exercise influence on individual susceptibility to cancer.

引用

页码：89 / 92

页数：4

共 25 条

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