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重复经颅磁刺激治疗脑卒中后迟发性癫痫患者焦虑抑郁共病的疗效

被引：16
作者：
单峤 [1 ]
王世勋 [2 ]
王新军 [1 ]
机构：
[1] 郑州大学第五附属医院神经外科二病区
[2] 河南省项城市第一人民医院神经外科
来源：
实用医学杂志 | 2013年 / 29卷 / 24期
关键词：
卒中; 迟发性癫痫; 焦虑抑郁共病; 血流变; 细胞因子;
D O I：
暂无
中图分类号：
R742.1 [癫痫];
学科分类号：
摘要：
目的:分析重复经颅磁刺激(rTMS)治疗脑卒中后迟发性癫痫患者焦虑抑郁共病(CAD)的临床疗效。方法:选择脑卒中后合并CAD的迟发性癫痫患者64例,随机分为对照组及治疗组,对照组采取常规治疗,观察组在此基础上采用rTMS进行治疗。对两组患者治疗前后行汉密尔顿焦虑量表(HAMA)及汉密尔顿抑郁量表(HAMD)、临床神经功能缺损程度评分(NFDS)测定,并检测血液流变学,测定IL-1β、IL-6、TNF-α。结果:治疗组治疗后HAMA、HAMD、NFDS较治疗前有显著性改善(P<0.05),且较对照组改善更明显(P<0.05)。治疗组治疗后高切粘度、低切粘度、血小板聚集指数与治疗前及对照组相比较差异有显著性(P<0.05)。治疗组治疗后IL-1β、IL-6与治疗前及对照组相比较差异有显著性(P<0.05)。相关性分析示IL-1β与高切粘度、低切粘度、血浆比粘度、血小板聚集指数呈显著正相关(P<0.05)。IL-6与低切粘度、血浆比粘度呈显著正相关(P<0.05)。结论:rTMS可有效缓解脑卒中后合并CAD的迟发性癫痫患者焦虑抑郁状态,这与rTMS改善血液流变学及细胞因子水平密切相关。
引用
收藏
页码：4000 / 4003
页数：4
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