ω-3多不饱和脂肪酸逆转肠外营养所致肝损害的实验室观察

被引：6

作者：

胥子玮 ^{[1
]}

李幼生 ^{[1
]}

王剑 ^{[1
]}

吴波 ^{[2
]}

李元新 ^{[1
]}

黎介寿 ^{[1
]}

机构：

[1] 南京大学医学院临床学院(南京军区南京总医院)解放军普通外科研究所

[2] 南京大学医学院临床学院(南京军区南京总医院)病理科

来源：

肠外与肠内营养 | 2012年 / 19卷 / 04期

关键词：

ω-3多不饱和脂肪酸; 鱼油; 肠外营养相关肝损害; 短肠综合征; 胆汁淤积;

D O I：

10.16151/j.1007-810x.2012.04.003

中图分类号：

R459.3 [饮食疗法、临床营养学];

学科分类号：

100231 [临床病理学];

摘要：

目的:从临床实验室和组织学观察ω-3多不饱和脂肪酸(ω-3PUFA)对成人肠外营养相关肝损害(PNALD)的作用。方法:选取15例长期行PN导致胆汁淤积(直接胆红素≥34μmol/L)的成人短肠综合征病人。动态观察病人应用ω-3PUFA前和治疗1个月内肝功能和血清游离脂肪酸谱的变化。同时行肝穿刺活检,观察治疗前和治疗1个月后的肝组织学改变。结果:ω-3PUFA治疗1个月后,80%(12/15)病人直接胆红素水平恢复正常,所有病人肝功能指标和血清游离脂肪酸谱均得到改善,从肝组织学上亦证实了这种效果。结论:ω-3PUFA能很好地逆转成人PNALD,并改善病人的血脂状况。

引用

页码：193 / 196

页数：4

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