腹主动脉瘤生物力学研究的新进展

被引：9

作者：

童建华 ^{[1
,2
]}

王贵学 ^{[2
]}

机构：

[1] 同济大学医学院上海东方医院生物医学工程及纳米科学研究院

[2] 重庆大学生物工程学院生物流变科学与技术教育部重点实验室

来源：

医用生物力学 | 2016年 / 31卷 / 05期

关键词：

腹主动脉瘤; 生物力学特性; 血栓; 破裂风险预测; 有限元分析;

D O I：

暂无

中图分类号：

R543.1 [主动脉疾病];

学科分类号：

100201 [内科学];

摘要：

腹主动脉瘤(abdominal aortic aneurysm,AAA)是腹主动脉局部呈肿瘤状扩张的血管疾病。如果不及时治疗,持续扩张的AAA将最终破裂,具有极高的死亡率。近年来,生物力学方法被广泛地应用于AAA临床破裂风险的评估预测中。相关研究成果也极大地增进了对于AAA病理机制的理解。首先讨论基于腔内血栓和AAA的生物力学测试方法,全面了解血栓及动脉瘤组织的多种力学特性以及力学特性变化对AAA在病理环境下生长及结构重建的影响;回顾一系列运用实验和计算生物力学手段预测AAA破裂风险的代表性研究成果,具体包括有限元分析AAA的管壁应力分布、评估破裂风险指数和判断破裂发生的具体位置等方面;重点阐述AAA中血栓的老化所导致的微观结构变化,并总结AAA生物力学研究的现状和未来挑战。

引用

页码：369 / 375

页数：7

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