阿尔茨海默病治疗药物研究进展

被引:13
作者
张倩 [1 ]
李建涛 [2 ]
宋春霞 [1 ]
王凤山 [3 ]
机构
[1] 山东大学(威海)海洋学院
[2] 威海市立医院
[3] 山东大学药学院
关键词
阿尔茨海默病; 免疫治疗剂; 钙离子拮抗剂;
D O I
暂无
中图分类号
R749.16 [];
学科分类号
100203 ;
摘要
<正>目前全球约3 600万人患有阿尔茨海默病(AD),在欧美主要城市人群中AD是仅次于癌症的第二大忧患,而在我国1984~2004年60岁以上人口发病率为1.6%〔1〕,我国AD患者总数已超过500万〔2〕。目前对于AD仍然缺乏特异性的治疗方法,研究重点仍是针对AD的各相关症状的药物。1胆碱酯酶抑制剂(CHEI)研究表明AD患者的大脑皮层、海马结构和边缘系统中胆
引用
收藏
页码:2282 / 2285
页数:4
相关论文
共 20 条
[11]  
Effect of Vitamin E Administration on the Elevated Oxygen Stress and the Telomeric and Subtelomeric Status in Alzheimer’s Disease[J] . Guan, Jing-zhi,Guan, Wei-ping,Maeda, Toyoki,Makino, Naoki.Gerontology . 2011 (1)
[12]  
A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease[J] . S. Salloway,R. Sperling,R. Keren,A.P. Porsteinsson,C.H. van Dyck,P.N. Tariot,S. Gilman,D. Arnold,S. Abushakra,C. Hernandez,G. Crans,E. Liang,G. Quinn,M. Bairu,A. Pastrak,J.M. Cedarbaum.Neurology . 2011 (13)
[13]  
The pharmacology of selegiline[J] . Kálmán Magyar.International Review of Neurobiology . 2011
[14]   A phase II trial of huperzine A in mild to moderate Alzheimer disease [J].
Rafii, M. S. ;
Walsh, S. ;
Little, J. T. ;
Behan, K. ;
Reynolds, B. ;
Ward, C. ;
Jin, S. ;
Thomas, R. ;
Aisen, P. S. .
NEUROLOGY, 2011, 76 (16) :1389-1394
[15]  
Tramiprosate in mild-to-moderate Alzheimer’s disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study). PS Aisen,S Gauthier,SH Ferris,D Saumier,D Haine,D Garceau,A Duong,J Suhy,J Oh,WC Lau,J Sampalis. Archives of medical science : AMS . 2011
[16]  
Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer’s disease: A 24-week, randomized, double-blind study[J] . Martin R. Farlow,Stephen Salloway,Pierre N. Tariot,Jane Yardley,Margaret L. Moline,Qin Wang,Elimor Brand-Schieber,Heng Zou,Timothy Hsu,Andrew Satlin.Clinical Therapeutics . 2010 (7)
[17]   Small molecule β-amyloid inhibitors that stabilize protofibrillar structures in vitro improve cognition and pathology in a mouse model of Alzheimer's disease [J].
Hawkes, Cheryl A. ;
Deng, Le-Hua ;
Shaw, James E. ;
Nitz, Mark ;
McLaurin, JoAnne .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2010, 31 (02) :203-213
[18]  
Anti-Amyloid-β Immunotherapy in Alzheimer’s Disease: ACC-001 Clinical Trials Are Ongoing[J] . J. Michael Ryan,Michael Grundman.Journal of Alzheimer’s Disease . 2009 (2)
[19]   Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-β oligomers [J].
Townsend, Matthew ;
Cleary, James P. ;
Mehta, Tapan ;
Hofmeister, Jacki ;
Lesne, Sylvain ;
O'Hare, Eugene ;
Walsh, Dominic M. ;
Selkoe, Dennis J. .
ANNALS OF NEUROLOGY, 2006, 60 (06) :668-676
[20]  
Pharmacotherapeutic approaches to the prevention of Alzheimer’s disease[J] . John B. Standridge.American Journal of Geriatric Pharmacotherapy . 2004 (2)