骨质疏松药物靶向治疗的研究进展

被引：8

作者：

应建伟 ^{[1
]}

李桂锦 ^{[1
]}

朱胤晟 ^{[1
]}

何帮剑 ^{[2
]}

姚新苗 ^{[2
]}

机构：

[1] 浙江中医药大学第三临床医学院

[2] 浙江省中山医院

来源：

浙江中医药大学学报 | 2013年 / 37卷 / 08期

关键词：

骨质疏松症; Wnt/β-catenin; 药物靶向治疗; 信号通路; 骨硬化蛋白;

D O I：

10.16466/j.issn1005-5509.2013.08.037

中图分类号：

R580 [];

学科分类号：

摘要：

[目的]综述近10年来骨质疏松药物靶向治疗的研究进展。[方法]通过检索国内外对成骨细胞Wnt/β-catenin信号通路认识及研究的文献,对骨质疏松药物靶向治疗不同作用机制进行总结。[结果]DKK1、GSK-3β、骨硬化蛋白的过度表达会抑制成骨细胞的活性及功能,而通过药物抑制通路中因子的表达对骨质疏松的治疗具有积极的意义。[结论]骨质疏松药物靶向治疗具有良好的前景。

引用

页码：1046 / 1048

页数：3

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