lncRNA的作用机制及其在自身免疫性疾病中的研究进展

被引：6

作者：

公丕霞

常远

李兆瀛

李呼伦

机构：

[1] 哈尔滨医科大学神经生物教研室

来源：

国际免疫学杂志 | 2018年 / 41卷 / 02期

关键词：

lncRNA; 自身免疫性疾病; 亚细胞定位; 作用机制;

D O I：

暂无

中图分类号：

R593.2 [自身免疫性疾病、结缔组织疾病];

学科分类号：

100201 [内科学];

摘要：

lncRNA(long non-coding RNA)是长度大于200个核苷酸的非编码RNA, 其能与DNA、RNA和蛋白质相互作用发挥多种生物学功能, 包括参与表观遗传调控、细胞周期调控、细胞分化调控和免疫应答等。越来越多的研究表明, lncRNA的表达失调与自身免疫性疾病的发生息息相关。lncRNA作用机制复杂多变、特异性强的特点为其深入研究带来了很多阻碍, 目前绝大部分lncRNA的功能和机制仍不明确。已有的研究表明lncRNA的亚细胞定位不同往往涉及不同的作用机制, 了解其亚细胞定位与作用机制之间的关联, 将推动LncRNA在多种疾病包括自身免疫性疾病中的深入研究。

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