瑞替普酶与阿替普酶在急性ST段抬高型心肌梗死溶栓治疗中的临床对比分析

被引：43

作者：

吕云

高彦

机构：

[1] 云南省圣约翰医院

来源：

现代中西医结合杂志 | 2014年 / 23卷 / 11期

关键词：

瑞替普酶; 阿替普酶; 急性ST段抬高型心肌梗死; 溶栓治疗;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

摘要：

目的探讨瑞替普酶与阿替普酶在急性ST段抬高型心肌梗死溶栓治疗中的应用效果。方法选取急性ST段抬高型心肌梗死患者98例,随机分为2组,对照组49例患者行阿替普酶溶栓治疗,观察组49例患者行瑞替普酶溶栓治疗,比较2组患者溶栓治疗的再通情况及并发症情况。结果 2组患者胸痛发作-到院就诊-溶栓治疗时间分布、心肌梗死部位的再通时间分布均无显著性差异(P均>0.05)。观察组溶栓治疗后再灌注心率失常发生率、并发症发生率、心功能衰竭发生率、病死率均低于对照组,观察组心电图ST段回落≥50%的发生率、完全回落的发生率均高于对照组,仅2组溶栓后并发症发生率比较有显著性差异(P<0.05)。结论瑞替普酶与阿替普酶均是急性ST段抬高型心肌梗死溶栓治疗的有效药物,可明显改善患者症状和预后,其中瑞替普酶的安全性更高。

引用

页码：1197 / 1199

页数：3

共 10 条

[1]

P2Y12 platelet reactivity after thrombolytic therapy for ST-segment elevation myocardial infarction [J].

Diego, Alejandro ;

Perez de Prado, Armando ;

Cuellas, Carlos ;

de Miguel, Antonio ;

Samaniego, Beatriz ;

Alonso-Rodriguez, David ;

Bangueses, Roi ;

Vega, Berta ;

Martin, Julia ;

Fernandez-Vazquez, Felipe .

THROMBOSIS RESEARCH, 2012, 130 (03) :E31-E36

[2]

Late microvascular obstruction after acute myocardial infarction: Relation with cardiac and inflammatory markers [J].

Mayr, Agnes ;

Klug, Gert ;

Schocke, Michael ;

Trieb, Thomas ;

Mair, Johannes ;

Pedarnig, Kathrin ;

Pachinger, Otmar ;

Jaschke, Werner ;

Metzler, Bernhard .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2012, 157 (03) :391-396

[3]

Clinical impact of thrombus aspiration during primary percutaneous coronary intervention: Results from Korea Acute Myocardial Infarction Registry [J].

Hachinohe, Daisuke ;

Jeong, Myung Ho ;

Saito, Shigeru ;

Kim, Min Chol ;

Cho, Kyung Hoon ;

Ahmed, Khurshid ;

Hwang, Seung Hwan ;

Lee, Min Goo ;

Sim, Doo Sun ;

Park, Keun-Ho ;

Kim, Ju Han ;

Hong, Young Joon ;

Ahn, Youngkeun ;

Kang, Jung Chaee ;

Kim, Jong Hyun ;

Chae, Shung Chull ;

Kim, Young Jo ;

Hur, Seung Ho ;

Seong, In Whan ;

Hong, Taek Jong ;

Choi, Donghoon ;

Cho, Myeong Chan ;

Kim, Chong Jin ;

Seung, Ki Bae ;

Chung, Wook Sung ;

Jang, Yang Soo ;

Rha, Seung Woon ;

Bae, Jang Ho ;

Park, Seung Jung .

JOURNAL OF CARDIOLOGY, 2012, 59 (03) :249-257

[4]

Reduction in Acute Myocardial Infarction Hospitalization after Implementation of a Smoking Ordinance [J].

Bruintjes, Gerrit ;

Bartelson, Becki Bucher ;

Hurst, Paul ;

Levinson, Arnold H. ;

Hokanson, John E. ;

Krantz, Mori J. .

AMERICAN JOURNAL OF MEDICINE, 2011, 124 (07) :647-654

[5]

Benefit of Early Statin Therapy in Patients With Acute Myocardial Infarction Who Have Extremely Low Low-Density Lipoprotein Cholesterol [J].

Lee, Ki Hong ;

Jeong, Myung Ho ;

Kim, Ha Mi ;

Ahn, Youngkeun ;

Kim, Jong Hyun ;

Chae, Shung Chull ;

Kim, Young Jo ;

Hur, Seung Ho ;

Seong, In Whan ;

Hong, Taek Jong ;

Choi, Dong Hoon ;

Cho, Myeong Chan ;

Kim, Chong Jin ;

Seung, Ki Bae ;

Chung, Wook Sung ;

Jang, Yang Soo ;

Rha, Seung Woon ;

Bae, Jang Ho ;

Cho, Jeong Gwan ;

Park, Seung Jung .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 58 (16) :1664-1671

[6]

AS-148: Impact of Statins on 12-Month Clinical Outcomes in Acute ST-Segment Elevation Myocardial Infarction Patients Who Received Thrombolytic Therapy.[J].Seung-Woon Rha;Lin Wang;Ji Young Park;Sureshkumar Ramasamy;Byoung Geol Choi;Ji Bak Kim;Seung Yong Shin;Cheol Ung Choi;Hong Euy Lim;Jin Won Kim;Eung Ju Kim;Chang Gyu Park;Hong Seog Seo;Dong Joo Oh;Young Keun Ahn;Myung Ho Jeong.The American Journal of Cardiology.2010, 9

[7]

低分子肝素联合阿替普酶治疗ST段抬高型急性心肌梗死患者的有效性和安全性研究.[J].刘广军;.中国医药指南.2012, 36

[8]

1150国产瑞替普酶与尿激酶在ST段抬高型急性心肌梗死治疗中的比较研究 [J].