脑卒中发病的分子机制

Stroke is the second leading cause of death and first leading cause of disability in China, the magnitude of established risk factor (such as smoking) for stroke may not be the same as seen in westerners. Lp(a), ox LDL, advanced glycation end products(AGES) and homocysteine in plasma have been indicated as emerging molecular risk factors to stroke, but not yet proven in Chinese stroke. Some other genetic risk factors have been addressed in recent years. We performed a genetic analysis of 72 polymorphism in 36 genes related to atherosclerosis, in a cohort study of 1375 cases and age, sex matched controls. The results indicate that apoE4 is the genetic risk factor for Chinese male stroke and patients carry C677T homologous mutation of MTHFR gene may be susceptible to stroke.