间充质干细胞归巢的研究进展

被引：16

作者：

邓启垣 ^{[1
]}

陈灿 ^{[2
]}

黄石安 ^{[2
]}

机构：

[1] 广东医学院研究生院

[2] 广东医学院附属医院心血管内科

来源：

医学综述 | 2010年 / 16卷 / 05期

关键词：

间充质干细胞; 归巢; 趋化因子; 趋化因子受体; 黏附分子;

D O I：

暂无

中图分类号：

R329.2 [人体细胞学];

学科分类号：

100107 [人体解剖与组织胚胎学（人体解剖学、组织与胚胎学）];

摘要：

间充质干细胞(MSCs)被认为是最有希望用于治疗多种疾病的一种非造血组织的多能干细胞,但是其靶向组织器官归巢率偏低,影响了其作为干细胞疗法的效果。许多研究发现,MSCs归巢过程的机制(包括参与的分子,如趋化因子及其受体和黏附分子等)与白细胞向炎性组织的归巢过程十分相似。随之,根据上述机制,通过MSCs移植前预处理,MSCs归巢率有所提高,从而在一定程度上提高了MSCs疗法的效果。进一步深入研究MSCs归巢过程的相关机制可能是从根本上改善MSCs疗法疗效的切入点,进而扩展其治疗谱。

引用

页码：678 / 681

页数：4

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