乌头碱致中枢神经毒性机制的研究进展

被引：30

作者：

汤春红

肖雪

段海真

喻安永

机构：

[1] 遵义医学院附属医院急诊科

来源：

广西医学 | 2018年 / 40卷 / 20期

关键词：

乌头碱; 中枢神经毒性; 机制; 综述;

D O I：

暂无

中图分类号：

R595.4 [药物中毒];

学科分类号：

100201 [内科学];

摘要：

乌头类中药是一类重要的中药材,在全世界得到了广泛的应用。然而由于其中毒剂量与治疗剂量相当接近,中毒事件时有发生。过去十几年间,全世界大约共报告了5 000例乌头碱中毒事件,中毒者常出现中枢神经系统的症状。尽管相关研究阐述了乌头碱致中枢神经毒性的机制,但迄今为止仍不明确。本文从乌头碱影响神经细胞离子通道、影响神经递质、干扰神经细胞能量代谢、诱导神经细胞凋亡等方面对乌头碱致中枢神经毒性机制进行综述。

引用

页码：2448 / 2451

页数：4

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